Application of Deamidated Gliadin Antibodies in the Follow-Up of Treated Celiac Disease

PloS One
Luc de ChaisemartinMarie-Agnès Dragon-Durey

Abstract

The role of serological tests such as IgA anti-transglutaminase autoantibodies has become increasingly important in celiac disease (CD) diagnosis. However, the efficiency of these tests for patient follow-up is controversial. We investigated the correlation of 12 different serological tests, including recent deamidated gliadin and actin IgA tests, with villous atrophy (VA) in a retrospective cohort of treated celiac patients. Serum samples were collected from 100 treated CD patients who had intestinal biopsy in the course of their follow-up. Antibodies against transglutaminase, deamidated gliadin peptides, and native gliadin were measured, along with IgA anti-actin. The biopsy slides were all blind-reviewed and scored according to Marsh classification. For all deamidated gliadin and transglutaminase tests, we found that a positive result was significantly associated with persistence of intestinal VA, with a diagnostic efficacy up to 80%. Furthermore, antibodies titers directly correlated with the degree of VA, indicating a strong link between disease activity and presence of antibodies in the serum. Interestingly, the tests with the highest association with persistent VA were those for deamidated gliadin IgG. Using a test posit...Continue Reading

References

Mar 10, 2000·The American Journal of Gastroenterology·W DickeyS A McMillan
Sep 15, 2000·Gut·M G ClementeS De Virgiliis
Jun 18, 2003·The American Journal of Gastroenterology·Kouroche VahediClaude Matuchansky
Aug 17, 2004·The American Journal of Gastroenterology·M G ClementeS De Virgiliis
Apr 2, 2005·BMJ : British Medical Journal·R G Peter Watson
Jun 1, 2005·Best Practice & Research. Clinical Gastroenterology·Peter H R GreenMichael N Marsh
Jul 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emilia SugaiJulio C Bai
Oct 6, 2006·Journal of Clinical Pathology·B C DicksonR Chetty
Jul 27, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A CarroccioS M La Chiusa
Aug 9, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Daniel Agardh
Sep 18, 2007·Journal of Pediatric Gastroenterology and Nutrition·Edwin LiuEdward J Hoffenberg
Oct 20, 2007·Alimentary Pharmacology & Therapeutics·D A LefflerC P Kelly
Oct 26, 2007·The New England Journal of Medicine·Peter H R Green, Christophe Cellier
Nov 7, 2007·Digestive Diseases and Sciences·Umberto VoltaFrancesco B Bianchi
Feb 29, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shadi RashtakJoseph A Murray
Feb 29, 2008·Digestive Diseases and Sciences·Maria Letizia FaliniFabio Forlani
Mar 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andrew D HopperDavid S Sanders
Apr 1, 2008·Journal of Pediatric Gastroenterology and Nutrition·Ilma R Korponay-SzabóMarkku Mäki
May 26, 2009·Journal of Pediatric Gastroenterology and Nutrition·Christian PrauseThomas Mothes
Feb 11, 2010·The American Journal of Gastroenterology·Alberto Rubio-TapiaJoseph A Murray
Feb 23, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pieter VermeerschXavier Bossuyt
Jun 23, 2011·Journal of Pediatric Gastroenterology and Nutrition·Alice MonzaniGiuseppina Oderda
Jul 28, 2011·Arthritis and Rheumatism·Lotte A van de StadtDirkjan van Schaardenburg
Oct 25, 2011·Journal of Pediatric Gastroenterology and Nutrition·Kalle KurppaKatri Kaukinen
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·S HusbyUNKNOWN European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
May 31, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nikolaos K GatselisGeorge N Dalekos
Jul 10, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pieter VermeerschXavier Bossuyt
Oct 2, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Barbara ZaniniAlberto Lanzini
Dec 21, 2012·The New England Journal of Medicine·Alessio Fasano, Carlo Catassi

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Citations

Jan 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Maureen M LeonardAlessio Fasano
Mar 2, 2016·Revista chilena de pediatría·Elisa A Aranda, Magdalena Araya
Aug 12, 2017·Italian Journal of Pediatrics·Michele AriglianiPaola Cogo
Aug 1, 2020·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Omar I SaadahJamil A Al-Mughales
Feb 4, 2019·Gastroenterology Clinics of North America·Georgia Malamut, Christophe Cellier
Mar 22, 2019·International Archives of Allergy and Immunology·David SpoerlPascale Roux-Lombard

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Methods Mentioned

BETA
biopsy
biopsies
ELISA
Assay
antibody profile

Software Mentioned

MedCalc
GraphPad PRISM
GraphPad
Genesis

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