Application of diffusion-edited and solvent suppression ¹H-NMR to the direct analysis of markers in valerian-hop liquid herbal products

Phytochemical Analysis : PCA
J M PrietoM Zloh

Abstract

The rising trend to consume herbal products for the treatment and/or prevention of minor ailments together with their chemical and pharmacological complexity means there is an urgent need to develop new approaches to their quality and stability. This work looks at the application of one-dimensional diffusion-edited (1)H-NMR spectroscopy (1D DOSY) and (1)H-NMR with suppression of the ethanol and water signals to the characterisation of quality and stability markers in multi-component herbal medicines/food supplements. The experiments were performed with commercial tinctures of Valeriana officinalis L. (valerian), expired and non-expired, as well as its combination with Hummulus lupulus L. (hops), which is one of the most popular blends of relaxant herbs. These techniques did not require purification or evaporation of components for the qualitative analysis of the mixture, but only the addition of D2 O and TSP. The best diagnostic signals were found at δ 7 ppm (H-11, valerenic acid), δ 4.2 ppm (H-1, hydroxyvalerenic acid) and δ 1.5-1.8 ppm (methyl groups in prenylated moieties, α-acids/prenylated flavones). This work concludes on the potential value of 1D DOSY (1)H-NMR to provide additional assurance of quality in complex natural...Continue Reading

References

Feb 1, 1988·Journal of Ethnopharmacology·P J Houghton
Apr 17, 1998·Journal of Magnetic Resonance·H BarjatA G Swanson
Nov 14, 2001·Phytochemical Analysis : PCA·A C HoekR Verpoorte
Dec 13, 2001·Journal of Magnetic Resonance·W H Otto, C K Larive
Aug 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephane VielStefano Caldarelli
Jun 10, 2004·Journal of Agricultural and Food Chemistry·Mathias NilssonGareth A Morris
Jul 13, 2007·Phytochemical Analysis : PCA·Alfi KhatibRobert Verpoorte

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Citations

Dec 17, 2016·Phytochemical Analysis : PCA·Pantelis CharisiadisIoannis P Gerothanassis

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