Application of directed orthometalation toward the synthesis of aryl siloxanes

The Journal of Organic Chemistry
W Michael Seganish, Philip DeShong

Abstract

A selection of ortho-substituted aryl siloxanes have been prepared by directed orthometalation protocols. These siloxanes can be prepared in high yields and purity by use of a diverse selection of ortho-directing groups and electrophilic siloxane derivatives. The siloxanes are employed in palladium-catalyzed cross-coupling reactions with aryl bromides to generate unsymmetrical ortho-substituted biaryls in good to excellent yields.

Citations

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