Application of dose compensation in image-guided radiotherapy of prostate cancer

Physics in Medicine and Biology
Qiuwen WuD Yan

Abstract

In image-guided radiation therapy (IGRT), volumetric information on patient anatomy at treatment conditions is made available with in-room imaging devices capable of cone-beam CT. Setup error and inter-fraction rigid motion can be corrected online. The planning margin can therefore be reduced significantly. However, to compensate for uncertainties including organ deformation and intra-fraction motion, offline evaluation and replanning are necessary. The purpose of this study is to investigate the use of an offline dose compensation technique to further reduce the margin safely. In IGRT, online CT scan, rigid image registration and setup correction are performed at each fraction. Later the regions of interest are registered offline between treatment and planning CTs using a finite element method to account for non-rigid organ motion. Cumulative dose distribution is calculated and compared with the prescription dose. The discrepancy, if found significant, is repaired using the dose compensation technique, in which the cumulative dose distribution is incorporated in adaptive IMRT planning for future fractions. Two compensation schedules were tested in this study: single compensation at the end of the treatment course and compensat...Continue Reading

References

Dec 1, 1995·International Journal of Radiation Oncology, Biology, Physics·M van HerkJ V Lebesque
Nov 7, 1998·International Journal of Radiation Oncology, Biology, Physics·J A AntolakA Pollack
May 29, 1999·International Journal of Radiation Oncology, Biology, Physics·D YanJ W Wong
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·D YanA Martinez
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Dale LitzenbergJames M Balter
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Aart J NederveenJan J W Lagendijk
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Qiuwen WuRupert Schmidt-Ullrich
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Michael G HermanBernard F King
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Michel J GhilezanAlvaro A Martinez
Jun 29, 2005·Seminars in Radiation Oncology·David A Jaffray

❮ Previous
Next ❯

Citations

Aug 8, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Marta Rodríguez Cordón, Carlos Ferrer Albiach
Jul 17, 2013·Journal of Radiation Research·V ZambranoD Georg
May 26, 2011·The Cancer Journal·Qingrong Jackie WuFang-Fang Yin
Apr 24, 2010·The Oncologist·Laura A Dawson, Cynthia Ménard
Mar 4, 2008·Nihon Hoshasen Gijutsu Gakkai zasshi·Toru TakakuraYuzo Kikuchi
Jun 1, 2014·Medical Physics·Wouter CrijnsFrank Van den Heuvel
Dec 24, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·H-L ChaoJ C-H Cheng
Oct 22, 2013·Physics in Medicine and Biology·Ning WenIndrin J Chetty
May 15, 2013·International Journal of Radiation Oncology, Biology, Physics·Jennifer De Los SantosIndrin J Chetty
Mar 14, 2014·Practical Radiation Oncology·Chengliang YangX Allen Li
Nov 19, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G CazoulatR de Crevoisier
Mar 12, 2010·Seminars in Radiation Oncology·Michel GhilezanAlvaro Martinez
Jul 14, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Fritz A LermaCedric X Yu
Nov 4, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Derek SchulzeTiezhi Zhang
Nov 21, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan J W LagendijkUulke A van der Heide
Oct 31, 2007·International Journal of Radiation Oncology, Biology, Physics·Jennifer C O'DanielLei Dong
Jan 2, 2007·International Journal of Radiation Oncology, Biology, Physics·Tianfang Li, Lei Xing
May 21, 2008·BJU International·Eivind A SteinsvikKarsten Eilertsen
Mar 20, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mohamed NassefRenaud de Crevoisier
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Qiuwen WuAlvaro Martinez
Oct 6, 2009·International Journal of Radiation Oncology, Biology, Physics·Qiuwen WuAlvaro Martinez
Nov 30, 2010·Journal of Oncology·Taoran LiQ Jackie Wu
May 6, 2015·PloS One·Velibor V Mišić, Timothy C Y Chan
Oct 2, 2007·Seminars in Radiation Oncology·Lei XingPaul Keall
Jun 20, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yoshitomo AbeKeiichi Jingu
Aug 1, 2007·Physics in Medicine and Biology·Adam de la ZerdaLei Xing
Jan 18, 2008·Physics in Medicine and Biology·Q Jackie WuFang-Fang Yin
Feb 1, 2013·Physics in Medicine and Biology·Wenjing ChenEike Rietzel
Aug 13, 2008·Physics in Medicine and Biology·Christos Antypas, Evaggelos Pantelis
Jul 7, 2011·Technology in Cancer Research & Treatment·Justin C ParkWilliam Y Song
Oct 29, 2021·Physics in Medicine and Biology·Harald PaganettiBrian Winey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.