Application of eudragit RS to thermo-sensitive drug delivery systems. I. Thermo-sensitive drug release from acetaminophen matrix tablets consisting of eudragit RS/PEG 400 blend polymers

Chemical & Pharmaceutical Bulletin
Junya FujimoriKatsuhide Terada

Abstract

In order to develop the polymer materials having temperature-sensitive and high biological safety, Eudragit RS-PO and polyethylene glycol 400 (PEG 400) blend polymers (EPG) were prepared. The EPGs that have the glass transition temperature (Tg) at around the body temperature were prepared by the addition of 5--13% PEG 400 to Eudragit RS. As glassy polymers are not in thermodynamic equilibrium below their Tg, the effects of isothermal aging on the T(g)s of Eudragit RS and EPG containing 10% PEG 400 (10% EPG) were also studied at various aging temperatures. The Tg values of Eudragit RS increased with the aging time and after 30 d of aging, they apparently reached constant values which markedly differed depending on the aging temperatures. On the other hand, the Tg values of 10% EPG were almost independent of the aging temperature and reached around 33 degrees C at 30 d after aging. The ability as thermo-sensitive polymer of EPG was evaluated by the dissolution test of the acetaminophen (AAP) matrix tablets prepared with EPG. The AAP release rate from the EPG matrix tablets slightly changed below the Tg of tablets, and then, it markedly increased above the Tg. Considering high biological safety of Eudragit RS and PEG 400, EPG migh...Continue Reading

References

Oct 1, 1986·Chemical & Pharmaceutical Bulletin·E FukuokaS Yamamura
Feb 1, 1996·Pharmaceutical Research·A SerresS W Kim

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Citations

Mar 23, 2013·International Journal of Pharmaceutics·Marco CespiGiovanni Filippo Palmieri
Jul 31, 2012·AAPS PharmSciTech·Elham KhodaverdiFatemeh Sadeghi
Aug 8, 2008·Drug Development and Industrial Pharmacy·Xiong ZhangRui Yang
Jan 25, 2008·Drug Development and Industrial Pharmacy·Dinesh Mahadeorao MorkhadeSiddheshwar B Joshi
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Junya FujimoriKatsuhide Terada
Dec 8, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Koichiro UtoTakao Aoyagi
Aug 16, 2018·Royal Society Open Science·P RavichandranAltaf H Basta
Jul 7, 2007·Pharmaceutical Development and Technology·Grant Heinicke, Joseph B Schwartz
Feb 20, 2018·Bio-medical Materials and Engineering·Hediye Irem OzgunduzNil Acarali

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