PMID: 8595161Feb 1, 1996Paper

Application of fusogenic liposomes containing fragment A of diphtheria toxin to cancer therapy

British Journal of Cancer
H MizuguchiT Mayumi

Abstract

Previously we reported that fusogenic liposomes, prepared by fusing simple liposomes with Sendai virus particles, could introduce their contents directly and efficiently into the cytoplasm. In this study, we examined the anti-tumour activity of fusogenic liposomes containing fragment A of diphtheria toxin (DTA). Fusogenic liposomes containing DTA showed high cytotoxicity against sarcoma-180 (S-180) cells in vitro. When these liposomes were administered into the abdominal cavity of ddY mice carrying S-180, tumour cells completely disappeared in four of six tumour-bearing mice without decrease in body weight. Neither simple liposomes containing DTA nor empty fusogenic liposomes had any effect on tumour suppression. We conclude that fusogenic liposomes containing DTA are new and potentially effective tools for the treatment of ascites tumours without any severe side-effects.

Citations

Dec 25, 2004·Drug Metabolism and Pharmacokinetics·Shinsaku Nakagawa, Tadanori Mayumi
Feb 3, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Jun KunisawaHiroshi Kiyono
Apr 20, 2004·Drug Development and Industrial Pharmacy·Ying HuYun Xia
May 3, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tomoaki YoshikawaShinsaku Nakagawa
Jul 6, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tadanori Mayumi
Nov 7, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Martin P StewartGaurav Sahay
Oct 6, 2001·Journal of Biomaterials Science. Polymer Edition·M Yokoyama, T Okano
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Tomoaki YoshikawaShinsaku Nakagawa
Aug 20, 2010·Pharmaceutical Research·Yogita KrishnamachariAliasger K Salem
Aug 5, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Naoki Okada
Jan 1, 1997·Critical Reviews in Biotechnology·I Hapala
Dec 17, 1997·Biochemical and Biophysical Research Communications·T NakanishiT Mayumi
Aug 12, 1999·Biochemical and Biophysical Research Communications·A HayashiT Mayumi
May 8, 1997·Biochemical and Biophysical Research Communications·H MizuguchiT Mayumi
Aug 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·S ImazuT Mayumi
Sep 19, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M NakanishiT Mayumi
Sep 2, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·T NakanishiT Mayumi
Jun 6, 2000·Advanced Drug Delivery Reviews·I MartinR M Epand
Sep 1, 1996·Cancer Treatment Reviews·M RansonJ Margison
Nov 28, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akira HayashiShinsaku Nakagawa
Oct 28, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andrea L J Marschall

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