Abstract
In this paper, we present a novel implementation of a dose calculation application, based on the GEANT4 Monte Carlo toolkit. Validation studies were performed with an homogeneous water phantom and an Alderson-Rando anthropomorphic phantom both irradiated with high-energy photon beams produced by a clinical linear accelerator. As input, this tool requires computer tomography images for automatic codification of voxel-based geometries and phase-space distributions to characterize the incident radiation field. Simulation results were compared with ionization chamber, thermoluminescent dosimetry data and commercial treatment planning system calculations. In homogeneous water phantom, overall agreement with measurements were within 1-2%. For anthropomorphic simulated setups (thorax and head irradiation) mean differences between GEANT4 and TLD measurements were less than 2%. Significant differences between GEANT4 and a semi-analytical algorithm implemented in the treatment planning system, were found in low-density regions, such as air cavities with strong electronic disequilibrium.
References
Jul 1, 1991·Physics in Medicine and Biology·P Andreo
May 1, 1993·Medical Physics·C X Yu, J W Wong
Mar 1, 1993·Medical Physics·T BortfeldB Rhein
Jan 1, 1996·Physics in Medicine and Biology·U SchneiderA Lomax
Aug 1, 1996·International Journal of Radiation Oncology, Biology, Physics·P M OstwaldC S Hamilton
May 5, 1999·Medical Physics·H Zaidi
Oct 20, 1999·Radiation and Environmental Biophysics·A E Nahum
Dec 10, 1999·Physics in Medicine and Biology·A Ahnesjö, M M Aspradakis
Jan 1, 2000·Physics in Medicine and Biology·J V SiebersR Mohan
Mar 4, 2000·Physics in Medicine and Biology·W SchneiderW Schlegel
Jul 21, 2000·Medical Physics·M R ArnfieldR Mohan
Aug 16, 2000·Physics in Medicine and Biology·R D LewisC J Evans
Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·L WangC S Chui
Feb 28, 2002·Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms·E R Benton, E V Benton
Jul 18, 2002·Radiation Protection Dosimetry·S RoeslerH Schraube
Aug 1, 2002·Medical Physics·Richard TaschereauJean Pouliot
Sep 25, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·P RodriguesM C Lopes
Citations
Nov 29, 2012·Australasian Physical & Engineering Sciences in Medicine·C M PooleC M Langton
Feb 23, 2011·Nuklearmedizin. Nuclear Medicine·A A Parach, H Rajabi
Sep 25, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·P RodriguesM C Lopes
Jun 13, 2018·Journal of Cancer Research and Therapeutics·Seydeh Zahra GhaseminezhadHossein Rajabi
Sep 9, 2005·Physics in Medicine and Biology·Hongyu JiangHarald Paganetti
Oct 28, 2019·Physics in Medicine and Biology·Daniel S BadaliTobias Funk
Jan 21, 2011·Physics in Medicine and Biology·L GrevillotD Sarrut
Dec 20, 2017·Physics in Medicine and Biology·Pedro Arce, Juan Ignacio Lagares
Mar 8, 2020·Radiation Protection Dosimetry·Serdar Charyyev, C-K Chris Wang
Dec 29, 2020·Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï·V V ChumakT V Treskunova