Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

International Journal of Pharmaceutics
Amanda SolaimanAmal Ali Elkordy

Abstract

Despite the popularity of orally fast disintegrating tablets (FDTs), their formulation can sometimes be challenging, producing tablets with either poor mechanical properties or high disintegration times. The aim of this research was to enhance the properties of FDTs produced by direct compression to have both sufficient hardness to withstand manual handling, and rapid disintegration time. General multilevel factorial design was applied to optimise and evaluate main and interaction effects of independent variables (i) disintegrant concentration, (ii) % filler (Disintequick MCC-25) to mannitol on the responses hardness, tensile strength and disintegration time. In this experiment mannitol was used as a diluent, Disintequick MCC-25 (to best of our knowledge there is no publication available yet for its use with FDTs) was termed in this study as a filler and croscaremellose sodium was used as the superdisintegrant. Seven formulations were prepared following a progressive two-stage approach. Each stage involved the change in the ratio of excipients (Mannitol:Filler) (1:0), (1:0.25), (1:0.50), (1:1), (0.50:1), (0.25:1), (0:1) w/w and concentration of superdisintegrant (1%, 3%, 5%, 7%, 10% w/w). All FDTs were tested for different para...Continue Reading

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Citations

Apr 21, 2017·Drug Development and Industrial Pharmacy·Yuri Ikeuchi-TakahashiHiraku Onishi
Apr 28, 2018·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Tong WuXiangrong Zhang
Feb 23, 2018·Journal of Dietary Supplements·Muhammad Azhar AliSadaf Muneer
Jun 21, 2021·Advanced Drug Delivery Reviews·Muhammad Sohail ArshadKendal Pitt
Sep 3, 2020·Drug Metabolism Letters·Preethi SudheerKavitha A Narayana

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