Application of growth-related sublethal endpoints in ecotoxicological assessments using a harpacticoid copepod

Aquatic Toxicology
Ulrika DahlMagnus Breitholtz

Abstract

In ecotoxicology, there is an increasing demand for sensitive sublethal endpoints. The primary aim of the present study was therefore to evaluate the relative sensitivity and usefulness of four sublethal endpoints - development time, body length, RNA content and growth rate - in the harpacticoid copepod Nitocra spinipes, using the reference molecule Simvastatin. Development time decreased significantly at low sublethal concentrations of Simvastatin (p < 0.001; F = 13.249; 0.16-1.6 microgL(-1)), while RNA content and body length increased significantly at 0.16 microgL(-1) (p < 0.001; F = 6.13) and 1.6 microgL(-1) (p < 0.01; F = 2.365), respectively. The growth rate increased significantly at 0.16-5 microgL(-1) (p<0.01-0.001). Hence, significant responses of growth-related traits were observed already at 0.16 microgL(-1), which is about 5,000 times lower than the acute toxicity (96 h-LC(50): 810 microgL(-1)). These results show that all assayed endpoints are very sensitive and indicate that current ecotoxicity testing used for environmental protection activities may underestimate the risk for harpacticoid copepods and most likely for other small invertebrates, when relying exclusively on acute toxicity measurements.

References

Jun 22, 2000·Risk Analysis : an Official Publication of the Society for Risk Analysis·G W Suter
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·K J GastonR D Mercer
Oct 25, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Richard M Sibly, Jim Hone
Mar 27, 2003·Aquatic Toxicology·Magnus BreitholtzLaurence Dinan
Feb 24, 2004·Annual Review of Physiology·Elizabeth P Dahlhoff
Jun 9, 2004·Journal of Insect Physiology·Kyung Jin MinMary Ann Rankin
Dec 29, 2004·Trends in Endocrinology and Metabolism : TEM·Edward B Dubrovsky
Aug 23, 2005·Environmental Toxicology and Chemistry·Udu Ibiam, Alastair Grant

❮ Previous
Next ❯

Citations

Nov 2, 2013·Ecotoxicology and Environmental Safety·Tristan J StringerLouis A Tremblay
Feb 3, 2009·Journal of Toxicology and Environmental Health. Part a·Bjørn Henrik HansenAnders J Olsen
May 24, 2014·Ecotoxicology and Environmental Safety·Marcos KrullFrancisco Barros
Feb 21, 2016·Aquatic Toxicology·Miguel M SantosTeresa Neuparth
Dec 24, 2011·Ecotoxicology and Environmental Safety·Magnus BreitholtzJerker Fick
Jun 30, 2010·Waste Management·S StiernströmM Breitholtz
Mar 17, 2010·Ecotoxicology and Environmental Safety·Nelly van der Hoeven
Dec 4, 2009·Journal of Hazardous Materials·Lúcia H M L M SantosM C B S M Montenegro
Jun 3, 2008·Ecotoxicology and Environmental Safety·Ulrika DahlMagnus Breitholtz
May 31, 2008·Chemosphere·Kyun-Woo LeeJae-Seong Lee
Apr 29, 2008·The Science of the Total Environment·Emily R CooperKarl Phillips
Apr 5, 2016·Environmental Science and Pollution Research International·V CunhaM Ferreira
Oct 1, 2011·Chemosphere·Ann-Kristin Eriksson WiklundMargaretha Adolfsson-Erici
Jan 25, 2008·Environmental Toxicology·Peter B KeyMichael H Fulton
Apr 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·André PereiraAngelina Pena
Jan 3, 2021·Ecotoxicology and Environmental Safety·Nélson AlvesMiguel M Santos
Mar 25, 2021·Environmental Toxicology and Chemistry·Josef Koch, Karel A C De Schamphelaere
Oct 20, 2018·Environmental Science & Technology·Torben LodeKatrine Borgå

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.