Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
María Teresa Donato, Laia Tolosa

Abstract

Safety evaluation of thousands of chemicals that are directly added to or come in contact with food is needed. Due to the central role of the liver in intermediary and energy metabolism and in the biotransformation of foreign compounds, the hepatotoxicity assessment is essential. New approach methodologies have been proposed for the safety evaluation of compounds with the idea of rapidly gaining insight into effects on biochemical mechanisms and cellular processes and screening large number of compounds. In this sense, high-content screening (HCS) is the application of automated microscopy and image analysis for better understanding of complex biological functions and mechanisms of toxicity. HCS multiparametric measurements have been shown to be a useful tool in early toxicity testing during drug development, but also in assessing the impact from food chemicals and environmental toxicants. Reviewing the use of cellular imaging technology in the safety evaluation of food-relevant chemicals offers evidence about the impact of this technology in safety assessment.

References

Aug 2, 2003·The New England Journal of Medicine·William M Lee
Apr 20, 2004·Assay and Drug Development Technologies·Kenneth A GiulianoD Lansing Taylor
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·B Kevin ParkDominic P Williams
Dec 15, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karen LauC Vyvyan Howard
Feb 28, 2006·Journal of Microscopy·Y LironZ Kam
Apr 6, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gebran Abboud, Neil Kaplowitz
Jul 20, 2007·Nature Chemical Biology·James IngleseDouglas S Auld
Jun 6, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jinghai J XuDavid de Graaf
Dec 20, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Martine PoulJean-Michel Poul
Jul 1, 2009·The Journal of Cell Biology·Jennifer C Waters
Aug 20, 2009·Current Medicinal Chemistry·Stefan RussmannIgnazio Grattagliano
Feb 20, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Weimiao YuSohail Ahmed
Apr 26, 2011·Nature Methods·Bjorn L MillardPeter K Sorger
Dec 6, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Laia TolosaM José Gómez-Lechón
Feb 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laia TolosaM José Gómez-Lechón
Aug 22, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H M MohanA W Baird
Nov 16, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Salman R KhetaniYvonne Will
Jun 7, 2013·The Journal of Pharmacy and Pharmacology·Laia TolosaM José Gómez-Lechón
Nov 6, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Helen GarsideJames Baumgartner
Jul 6, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ludovic PeyreRoger Rahmani
Oct 10, 2014·Expert Opinion on Drug Metabolism & Toxicology·M José Gómez-LechónM Teresa Donato
Feb 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brenton R WareSalman R Khetani
Oct 30, 2016·Critical Reviews in Food Science and Nutrition·Michalina Oplatowska-Stachowiak, Christopher T Elliott
Mar 5, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bas J BlaauboerJeroen Schuermans
Mar 10, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P J FerronL Le Hegarat
Mar 29, 2016·PloS One·Mashitoh Abd RahmanNajihah Mohd Hashim
Apr 23, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Agnes L KarmausKeith A Houck
Jun 9, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Andrew R CollinsMaria Dusinska
Jun 22, 2016·Archives of Toxicology·María José Gómez-Lechón, Laia Tolosa
Jul 20, 2016·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Nicola Bougen-ZhukovLit-Hsin Loo
Dec 13, 2016·Expert Opinion on Drug Discovery·Maria Teresa DonatoLaia Tolosa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.