Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution.

Environmental Research
Zhenjiang LiStefanie T Ebelt


Substantial research has investigated the adverse effects of traffic-related air pollutants (TRAP) on human health. Convincing associations between TRAP and respiratory and cardiovascular diseases are known, but the underlying biological mechanisms are not well established. High-resolution metabolomics (HRM) is a promising platform for untargeted characterization of molecular mechanisms between TRAP and health indexes. We examined metabolic perturbations associated with short-term exposures to TRAP, including carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), fine particulate matter (PM2.5), organic carbon (OC), and elemental carbon (EC) among 180 participants of the Center for Health Discovery and Well-Being (CHDWB), a cohort of Emory University-affiliated employees. A cross-sectional study was conducted on baseline visits of 180 CHDWB participants enrolled during 2008-2012, in whom HRM profiling was determined in plasma samples using liquid chromatography-high-resolution mass spectrometry with positive and negative electrospray ionization (ESI) modes. Ambient pollution concentrations were measured at an ambient monitor near downtown Atlanta. Metabolic perturbations associated with TRAP exposures were assessed following...Continue Reading


Jun 2, 1998·Drug Metabolism Reviews·E R Stadtman, B S Berlett
Jun 11, 1998·The Biochemical Journal·J KhanM Jacobs
Aug 31, 2000·American Journal of Epidemiology·P E TolbertM C White
Sep 13, 2003·American Journal of Respiratory and Critical Care Medicine·Abderrahim NemmarMarc F Hoylaerts
Oct 27, 2006·Journal of the Air & Waste Management Association·D Alan HansenReinhold Rasmussen
Nov 9, 2006·Free Radical Research·Earl R Stadtman
Mar 3, 2007·Mutation Research·Pavel RossnerRadim J Sram
May 13, 2008·Environmental Health Perspectives·Michael BrauerCatherine Karr
May 22, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Youngja ParkDean P Jones
May 30, 2009·Epidemiology·Lyndsey A DarrowPaige E Tolbert
Apr 10, 2010·American Journal of Respiratory and Critical Care Medicine·Matthew J StricklandPaige E Tolbert
Oct 27, 2010·Environmental Health : a Global Access Science Source·Lotte JacobsLuc Int Panis
Nov 5, 2010·Journal of the American Geriatrics Society·Kenneth L Brigham
Apr 23, 2011·Academic Medicine : Journal of the Association of American Medical Colleges·Kimberly J RaskMichael M E Johns
Jun 15, 2011·Environmental Health Perspectives·Moniek ZuurbierBert Brunekreef
Oct 11, 2011·Environmental Health : a Global Access Science Source·Michelle WilhelmBeate Ritz
May 1, 2012·Annual Review of Nutrition·Dean P JonesThomas R Ziegler
Jul 19, 2013·PLoS Computational Biology·Shuzhao LiBali Pulendran
Sep 1, 2007·Metabolomics : Official Journal of the Metabolomic Society·Lloyd W SumnerMark R Viant
Nov 12, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gary W Miller, Dean P Jones
Jan 31, 2014·Environmental Science & Technology·Emma L SchymanskiJuliane Hollender
Dec 6, 2014·Occupational and Environmental Medicine·Nadine Janet KubeschMark J Nieuwenhuijsen
Jan 8, 2015·Journal of Personalized Medicine·Rubina TabassumGreg Gibson
Mar 24, 2015·Frontiers in Bioengineering and Biotechnology·Arnald AlonsoAntonio Julià
Mar 1, 2013·Metabolomics : Official Journal of the Metabolomic Society·Quinlyn A SoltowDean P Jones
Nov 28, 2015·Neurotoxicology·Lucio G CostaPamela J Roqué
Jan 9, 2016·American Journal of Respiratory and Critical Care Medicine·Desinia B MillerUrmila P Kodavanti
Apr 23, 2016·Environmental Research·Yueh-Hsiu Mathilda ChiuFrancine Laden
Aug 9, 2016·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Hyungryul LimWon-Jun Choi
Sep 16, 2016·Chemical Research in Toxicology·Karan UppalDean P Jones
Nov 5, 2016·Environmental Health : a Global Access Science Source·Jen-Hwa ChuFrancine Laden
May 11, 2017·Analytical Chemistry·Piia LiigandAnneli Kruve
Sep 21, 2017·Amino Acids·Yordan MartínezYulong Yin
Jul 11, 2018·Environment International·Ayoung JeongUNKNOWN EXPOsOMICS Consortium

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