Application of Hyperosmotic Nanoemulsions in Wound Healing: Partial Thickness Injury Model in Swine

Advances in Wound Care
Sean ConnellLynetta J Freeman

Abstract

Objective: In this work, we introduce a novel hyperosmotic nanoemulsion (HNE) topical agent for use in wound healing. These topical emulsion complexes combine a lipophilic thymol nanoemulsion with a hyperosmotic saccharide matrix. This combination has been previously shown to possess synergistic antimicrobial activity against a host of common and drug-resistant pathogens in vitro. Approach: In this study, we present additional data to assess the safety and efficacy of these emulsions in a partial thickness injury model in swine. Ten wounds sized 2 × 3.5 cm were created in 18 pigs using an electrodermatome set at a depth of 0.76 mm. The wounds were subsequently contaminated with a cocktail of Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, and Candida albicans at 5 × 10(7) total colony forming unit per wound. Treatments were subdivided in the control group and emulsion concentrations at 0.0%, 0.01%, 0.03%, and 0.063% thymol content. Longitudinal metrics for wound healing included rate of reepithelialization, wound bed color measurements, amount of wound exudate, wound swab culture data, and histological examination at 4, 7, and 14 days. The cosmetics of the healed wound were obtained at day 14 with three-dimensio...Continue Reading

References

Apr 1, 1991·The British Journal of Surgery·M Subrahmanyam
May 1, 1996·Urology·M J HejaseC L Coogan
May 1, 1996·Critical Reviews in Toxicology·M A Hollinger
Jun 1, 1997·The Surgical Clinics of North America·M C Robson
Jun 13, 1998·Burns : Journal of the International Society for Burn Injuries·M Subrahmanyam
Apr 13, 2001·Journal of Tissue Viability·J Topham
Mar 17, 2004·Burns : Journal of the International Society for Burn Injuries·Vincent K M Poon, Andrew Burd
Mar 17, 2004·Current Opinion in Infectious Diseases·Ruth Edwards, Keith G Harding
Feb 22, 2005·Biomaterials·Ae-Ri Cho LeeKyung Chan Park
Dec 2, 2006·Burns : Journal of the International Society for Burn Injuries·Bishara S AtiyehSaad A Dibo
Aug 8, 2007·Archives of Dermatological Research·Chong-Ming ShiHideoki Ogawa
Jul 18, 2009·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Phyllis A Bonham
Oct 6, 2010·Journal of Diabetes Science and Technology·Atanu BiswasHoracio Rilo
Jun 28, 2011·Virulence·Tianhong DaiMichael R Hamblin
Dec 7, 2011·Human & Experimental Toxicology·V LomashS C Pant
Sep 29, 2012·Journal of Medical Microbiology·Sean ConnellRiyi Shi
May 15, 2013·Journal of Wound Care·J M Savage, S L A Jeffery
Dec 24, 2013·International Journal of Pharmaceutics·Serban BertesteanuRaluca Grigore

❮ Previous
Next ❯

Citations

Dec 12, 2018·The Journal of Pharmacy and Pharmacology·Michelle Fonseca CostaAdriana Gibara Guimarães

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

PhotoModeler
Adobe Photoshop
Photoshop

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.