Application of INADEQUATE NMR techniques for directly tracing out the carbon skeleton of a natural product

Phytochemical Analysis : PCA
Fyaz M D IsmailSatyajit D Sarker

Abstract

Nuclear magnetic resonance (NMR) measurement of 1 JCC coupling by two-dimensional (2D) INADEQUATE (incredible natural abundance double quantum transfer experiment), which is a special case of double-quantum (DQ) spectroscopy that offers unambiguous determination of 13 C-13 C spin-spin connectivities through the DQ transitions of the spin system, is especially suited to solving structures rich in quaternary carbons and poor in hydrogen content (Crews rule). To review published literature on the application of NMR methods to determine structure in the liquid-state, which specifically considers the interaction of a pair of carbon-13 (13 C) nuclei adjacent to one another, to allow direct tracing out of contiguous carbon connectivity using 2D INADEQUATE. A comprehensive literature search was implemented with various databases: Web of Knowledge, PubMed and SciFinder, and other relevant published materials including published monographs. The keywords used, in various combinations, with INADEQUATE being present in all combinations, in the search were 2D NMR, 1 JCC coupling, natural product, structure elucidation, 13 C-13 C connectivity, cryoprobe and CASE (computer-assisted structure elucidation)/PANACEA (protons and nitrogen and carbo...Continue Reading

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Citations

Mar 18, 2021·Magnetic Resonance in Chemistry : MRC·Philip J Sidebottom

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