PMID: 6408787Apr 1, 1983Paper

Application of indomethacin as a potentiator of lymphocyte blastogenesis in Brucella abortus exposed cattle

Veterinary Immunology and Immunopathology
J M KaneeneC C Muscoplat

Abstract

Lymphocytes from Brucella abortus field strain infected, strain 19 vaccinated, non-exposed and field strain infected, but immunologically unresponsive cattle were incubated with B. abortus antigen and indomethacin. There were significant increases (P less than 0.005) in the blastogenic responses, as measured by [3H] thymidine uptake, in cultures with indomethacin as compared to cultures without indomethacin. Lymphocyte blastogenic responses to B. abortus antigen were potentiated by indomethacin in both B. abortus exposed and non-exposed cultures. However, potentiation of sensitized lymphocyte blastogenic responses by indomethacin was significantly greater (P less than 0.005) than that in non-exposed lymphocytes. Additionally, indomethacin significantly potentiated Brucella-induced lymphocyte blastogenic responses in lymphocytes from anergic cattle.

References

Jan 1, 1979·Annals of the New York Academy of Sciences·D R WebbI Nowowiejski
Nov 3, 1977·The New England Journal of Medicine·J S GoodwinR C Williams
Sep 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·A A MihasB I Hirschowitz
Aug 1, 1974·The Journal of Clinical Investigation·V A Ferraris, F R DeRubertis

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Citations

Aug 1, 1985·Veterinary Immunology and Immunopathology·C L BaldwinA J Winter

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