PMID: 3760386Nov 1, 1986Paper

Application of information theory to decision analysis in potentially prostaglandin-responsive neonates

Journal of the American College of Cardiology
D A DanfordD G McNamara

Abstract

To define settings in which use of prostaglandin E1 before transfer from a community hospital to a tertiary care center benefits neonates with possible heart disease, information theory was used to predict the probability of a favorable response to prostaglandin therapy from the limited information of clinical variables. Records of 250 patients, newborn to 7 days old, with suspected heart disease were reviewed to assess six clinical variables (cyanosis, respiratory distress, heart murmur, pulse contour, hepatomegaly and prematurity). According to the anatomic and hemodynamic cardiovascular condition, each case was categorized as to whether a favorable response to prostaglandin E1 could be anticipated. Information content of each clinical variable with respect to prostaglandin responsiveness was determined, and patients were classified according to the most informative clinical variable. Stepwise extraction of information proceeded until remaining clinical variables added no significant information. Bayes' rule gave estimates of probability of prostaglandin-responsive defect in final subgroups for use in decision analysis. Cyanosis, murmur, small volume pulses and prematurity gave information about prostaglandin-responsive defec...Continue Reading

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Citations

Apr 20, 1991·BMJ : British Medical Journal·R C FranklinK Bull
Apr 26, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·D J Penny, L S Shekerdemian
Apr 28, 1999·Pediatric Clinics of North America·M P O'Laughlin
Jan 9, 2014·Journal of Paediatrics and Child Health·Neelam GuptaNeil Patel
Aug 1, 2015·Emergency Medicine Clinics of North America·Ashley M Strobel, Le N Lu
Aug 11, 2020·Journal of Paediatrics and Child Health·Stephanie M BoydKathryn Browning Carmo
Feb 3, 2005·Hospital Medicine·Joe Brierley
Apr 1, 1991·DICP : the Annals of Pharmacotherapy·M L Buck

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