Application of Innovative Hemocytometric Parameters and Algorithms for Improvement of Microcytic Anemia Discrimination

Hematology Reports
Margreet SchoorlPiet C M Bartels

Abstract

Hemocytometric parameters like red blood cell (RBC) count, mean red blood cell volume (MCV), reticulocyte count, red blood cell distribution width (RDW-SD) and zinc protoporphyrin (ZPP) are frequently established for discrimination between iron-deficiency anemia and thalassemia in subjects with microcytic erythropoiesis. However, no single marker or combination of tests is optimal for discrimination between iron-deficiency anemia and thalassemia. This is the reason why many algorithms have been introduced. However, application of conventional algorithms, only resulted in appropriate classification of 30-40% of subjects. In this mini-review the efficacy of innovative hematological parameters for detection of alterations in RBCs has been considered. It refers to parameters concerning hemoglobinization of RBCs and reticulocytes and the percentages microcytic and hypochromic RBCs, for discrimination between subjects with iron-deficiency anemia (IDA) or thalassemia as well as a combination of both. A new discriminating tool including the above mentioned parameters was developed, based on two precondition steps and discriminating algorithms. The percentage microcytic RBCs is considered in the first precondition step. MCV, RDW-SD and ...Continue Reading

Citations

Feb 9, 2017·Journal of Clinical Laboratory Analysis·Derya GuzelAtila Erol
Jul 27, 2018·International Journal of Laboratory Hematology·Shani Levy, Elise Schapkaitz
Mar 4, 2019··Immacolata AndolfoAntonella Gambale

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