PMID: 9188820May 9, 1997Paper

Application of ion mobility spectrometry to the rapid screening of methamphetamine incorporated in hair

Journal of Chromatography. B, Biomedical Sciences and Applications
Akihiro MikiHitoshi Tsuchihashi

Abstract

Using ion mobility spectrometry (IMS), a simple, sensitive and rapid screening for methamphetamine (MA) incorporated in user's hair has been developed. To completely unbind MA from hair matrix and to achieve its effective vaporization for the IMS detection, the hair sample was digested in 5 M NaOH (methanol-water, 4:1, v/v) solution prior to IMS measurement. MA in hair was semi-quantitatively detected by monitoring the digested hair sample employing dibenzylamine (DBA) as internal standard. The minimum amount of hair sample required was 2 mg and its digested sample was ample for four IMS measurements. The detection limit of MA in hair was 0.5 ng mg(-1). This proposed method was applicable to the semi-quantitative detection of MA in users' hair samples, and to the sectional analysis for MA in a limited amount of user's hair. The IMS results obtained were in good agreement with their GC-MS determination.

References


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Citations

Jul 22, 1998·Forensic Science International : Synergy·T KellerH Tsuchihashi
Feb 24, 2016·Analytical and Bioanalytical Chemistry·Maria de las Nieves PeiróMiguel de la Guardia
Jun 18, 2014·Drug Testing and Analysis·Sergio ArmentaNieves Galipienso
Jul 13, 2006·Forensic Science International : Synergy·Thomas KellerFabio Monticelli
Jan 20, 2009·Journal of Pharmaceutical and Biomedical Analysis·Connie M GryniewiczLucinda F Buhse
Jun 10, 2010·Rapid Communications in Mass Spectrometry : RCM·Mark Kwasnik, Facundo M Fernández
Apr 20, 2013·Talanta·Leonard T Demoranville, Jennifer R Verkouteren
May 6, 2021·Analytical and Bioanalytical Chemistry·Hui LiuYannan Chu
Apr 30, 2003·Biomedical Chromatography : BMC·Nariaki TakayamaKazuichi Hayakawa
Nov 1, 2013·Analytical Chemistry·Sergio ArmentaMarcelo Blanco

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