Application of Lutein and Zeaxanthin in nonproliferative diabetic retinopathy.

International Journal of Ophthalmology
Bo-Jie HuXiao-Rong Li

Abstract

To compare serum Lutein and Zeaxanthin (L/Z) concentrations between patients with nonproliferative diabetic retinopathy (NDR) and normal subjects, and to explore the effect of L/Z supplementation on serum L/Z level and visual function in NDR patients SUBJECTS WERE DIVIDED INTO THREE GROUPS: 30 NDR patients supplied with Lutein 6mg/d and Zeaxanthin 0.5mg/d for three months (DR Group), 30 NDR patients without L/Z supplementation (DR Control Group) and 30 normal subjects (Control Group). Serum L/Z concentrations were measured by liquid high-resolution chromatography (HPLC). Visual acuity was recorded at baseline, 1 month, 2 months and 3 months post initial supplementation. Serum L/Z concentration were measured at baseline, 1 month and 2 months post initial supplementation. Contrast sensitivity (CS) and fovea thickness were recorded at baseline and 3 months post initial supplementation. Mean serum lutein concentrations in DR group were 0.0686±0.0296µg/mL and zeaxanthin concentration was 0.0137±0.0059µg/mL. The L/Z level of DR group was significantly lower compared to the control group (lutein: 0.2302±0.1308µg/mL, zeaxanthin: 0.0456±0.0266µg/m, P=0.000). The concentration of lutein and zeaxanthin in the DR control group at base line...Continue Reading

Citations

Jan 29, 2016·Journal of Ophthalmology·Nicole K ScripsemaRichard B Rosen
Apr 17, 2019·Nutrients·Maria Grazia Rossino, Giovanni Casini
Aug 6, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mohammad FathalipourSoheil Hassanipour
Nov 17, 2016·International Journal of Retina and Vitreous·Verônica Castro LimaMichel Farah
Jun 21, 2020·Antioxidants·Ekaterina ProshkinaAlexey Moskalev
Jan 1, 2020·Journal of Diabetes and Metabolic Disorders·Ozra Tabatabaei-MalazyBagher Larijani
Aug 11, 2021·Nutrients·Drake W LemPinakin Gunvant Davey

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