PMID: 16506425Mar 2, 2006Paper

Application of magnetic resonance imaging to study pathophysiology in brain disease models

Methods in Molecular Medicine
Rick M Dijkhuizen

Abstract

Magnetic resonance imaging (MRI) provides a noninvasive and multimodal tool to study neurological disorders in experimental models. MRI experiments can be sensitized to various contrast parameters and, hence, enable comprehensive assessment of normal and abnormal brain physiology. Different conventional and novel MRI techniques have been developed that supply specific information on lesion location and size (e.g., T2- and diffusion-weighted MRI), alterations in tissue structure (e.g., magnetization transfer imaging and diffusion tensor imaging), perfusion deficits (perfusion MRI), brain activation (functional MRI), cell migration (cellular MRI), gene expression (molecular MRI), and more. The advantages of in vivo, longitudinal, and multiparametric studies with MRI provide unique opportunities for characterizing and delineating experimental models of neurological diseases and pathophysiological mechanisms, as well as spontaneous and treatment-induced recovery mechanisms.

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Rick M Dijkhuizen, Klaas Nicolay
Frontiers in Genetics
Marco Dominietto, Markus Rudin
Journal of Magnetic Resonance Imaging : JMRI
Jori S CarterPatrick J Bolan
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Kevin C ChanEd X Wu
© 2021 Meta ULC. All rights reserved