PMID: 9192353May 1, 1997Paper

Application of maximal removal rate of indocyanine green to the determination of hepatic functional mass in conscious rats

The Journal of Veterinary Medical Science
F Inage, K Furuhama

Abstract

We established a versatile method for the measurement of indocyanine green maximal removal rate (ICG Rmax) to detect hepatic functional mass in conscious rats using a repeated blood sampling procedure. On investigation of the optimal technical conditions, the appropriate intravenous administered doses of ICG were 2.5, 5, 10 or 20 mg/kg, and the best blood collection times for calculating plasma half-life at these doses were immediately before, and 4, 7 and 10 min after ICG injection. The interval among the respective ICG injections was more than 4 hr. In hepatectomized rats, the ICG Rmax value was reduced to about 50% and 20% of sham-operated rats in mean 2/3 and 4/5 liver resections, respectively, suggesting that it would almost extrapolate to hepatic surviving reserves under these experimental conditions. In rats treated subcutaneously with carbon tetrachloride (CCl4, 0.1 and 0.25 ml/kg) thrice weekly during a 17-week period (120 days), a decrease in ICG Rmax value did not correlate with increases in serum alanine transaminase (ALT), alkaline phosphatase (ALP) and total bilirubin values throughout the experimental periods. However, the reduced ICG Rmax well correlated with decreases in serum albumin and cholinesterase (CHE) v...Continue Reading

References

Feb 1, 1987·The Journal of Toxicological Sciences·K FuruhamaT Onodera
Oct 1, 1974·Annals of Surgery·F G MoodyJ S Aldrete
Sep 1, 1969·Toxicology and Applied Pharmacology·C D Klaassen, G L Plaa
Apr 10, 1967·JAMA : the Journal of the American Medical Association·W B Nelp, S M Larson
Sep 15, 1984·Toxicology and Applied Pharmacology·S KawasakiM Hanano
Jun 1, 1994·Journal of Pharmacological and Toxicological Methods·S HatanakaK Furuhama
Apr 1, 1960·The American Journal of Physiology·E F BANASZAKJ J SMITH

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Citations

Dec 15, 2010·Chemico-biological Interactions·Alessandra Milesi-HalléLaura P James
Jun 24, 1998·The Journal of Veterinary Medical Science·K Furuhama, K Yabe

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