Application of metabolomics: Focus on the quantification of organic acids in healthy adults

International Journal of Molecular Medicine
Dimitris TsoukalasAristides M Tsatsakis

Abstract

Metabolomics, a 'budding' discipline, may accurately reflect a specific phenotype which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in science has been proposed as a tool for the evaluation of the effects of epigenetic factors, such as nutrition, environment, drug and lifestyle on phenotype. Urine, being sterile, is easy to obtain and as it contains metabolized or non‑metabolized products, is a favored study material in the field of metabolomics. Urine organic acids (OAs) reflect the activity of main metabolic pathways and have been used to assess health status, nutritional status, vitamin deficiencies and response to xenobiotics. To date, a limited number of studies have been performed which actually define reference OA values in a healthy population and as reference range for epigenetic influences, and not as a reference to congenital metabolic diseases. The aim of the present study was thus the determination of reference values (RVs) for urine OA in a healthy adult population. Targeted metabolomics analysis of 22 OAs in the urine of 122 healthy adults by gas chromatography‑mass spectrometry, was conducted. Percentile distributions of the OA concentrations in urine, as a base for determini...Continue Reading

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Citations

Jan 18, 2019·Hormone Molecular Biology and Clinical Investigation·Gabriel CarneiroGustavo Monnerat
Jan 23, 2020·International Journal of Molecular Sciences·Marianna CaterinoIlaria Campesi
Aug 20, 2019·Eye & Contact Lens·Ayhan SağlikAtaman Gönel
Jun 14, 2020·International Journal of Environmental Research and Public Health·Denisa MarginăAristidis Tsatsakis
Nov 19, 2019·Frontiers in Molecular Biosciences·Dimitris TsoukalasDaniela Calina
Nov 30, 2019·Metabolites·Dimitris TsoukalasAristides Tsatsakis
Dec 12, 2020·Metabolites·Dimitris TsoukalasDaniela Calina
Aug 13, 2021·Frontiers in Plant Science·Yueqin ZhengYuanyuan Song

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