Application of micellar electrokinetic chromatography for analyzing antiviral drugs in pharmaceutical semisolid formulations

Journal of Pharmaceutical and Biomedical Analysis
R H NeubertB Colin

Abstract

The application of micellar electrokinetic chromatography (MEKC) to the determination of the antiviral drugs brivudin (BV) and aciclovir (AC) in pharmaceutical semisolid formulations was studied. A method was developed for separating AC and BV both from hydrophilic and from lipophilic semisolid formulations and for the rapid determination of BV and AC using MEKC. The detection limit, the effective mobility and the relative standard deviation of the migration times and of the peak areas were determined.

References

Sep 22, 1993·Journal of Chromatography·P Nebinger, M Koel

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Citations

Dec 5, 2006·Journal of Pharmaceutical and Biomedical Analysis·Paraskevas D Tzanavaras, Demetrius G Themelis
Jun 21, 2006·Electrophoresis·Kevin AltriaCari Sänger-van de Griend
Jan 31, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·A LoregianE F De Palo

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