Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[11C]Methylation with [11C]CH3I: Rapid Synthesis of [11C]Raclopride

Chemical & Pharmaceutical Bulletin
Hidekazu KawashimaHideo Saji

Abstract

A new radiolabeling method using a microreactor was developed for the rapid synthesis of [(11)C]raclopride. A chip bearing a Y-shaped mixing junction with a 200 µm (width)×20 µm (depth)×250 mm (length) flow channel was designed, and the efficiency of O-[11C]methylation was evaluated. Dimethyl sulfoxide solutions containing the O-desmethyl precursor or [11C]CH3I were introduced into separate injection ports by infusion syringes, and the radiochemical yields were measured under various conditions. The decay-corrected radiochemical yield of microreactor-derived [11C]raclopride reached 12% in 20 s at 25 °C, which was observed to increase with increasing temperature. In contrast, batch synthesis at 25 °C produced a yield of 5%: this indicates that this device could effectively achieve O-[11C]methylation in a shorter period of time. The microreactor technique may facilitate simple and efficient routine production of 11C-labeled compounds via O-[11C]methylation with [11C]CH3I.

References

May 1, 1992·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·B MazièreV W Pike
Aug 6, 1999·Annals of Nuclear Medicine·K IshiwataM Senda
Jan 25, 2002·Analytical Chemistry·Timothy J JohnsonLaurie E Locascio
Nov 18, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·J M GilliesJ Zweit
Feb 4, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Arkadij M ElizarovJames R Heath
Jul 9, 2010·Nuclear Medicine and Biology·Giancarlo PascaliPiero A Salvadori
Apr 29, 2011·Topics in Current Chemistry·Lorenzo CaprettoXunli Zhang

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