Application of modified in vitro screening procedure for identifying herbals possessing sulfonylurea-like activity

Journal of Ethnopharmacology
Y Rotshteyn, S W Zito

Abstract

We describe here the application of a modified in vitro procedure for identifying herbs potentially possessing sulfonylurea-like activity. The procedure consists of the combination of an SUR1 receptor binding assay and an insulin secretion assay in cultures of HIT-T15 cells. This procedure could be used as an initial step in identifying new safe and efficacious agents for the management of Type II diabetes. The application of this screening procedure to a set of selected herbs produced results that were consistent with the previously reported properties of those herbs. The collected data suggest that the hypoglycemic properties of bitter melon (Momordica charantia, Linn. Family, Cucurbitacea), cerasse (Momordica charantia, Linn. wild variety, Family, Cucurbitacea) and American ginseng (Panax quinquefolius, Linn., Family Araliacea) are at least partially due to their sulfonylurea-like activity.

References

Feb 1, 1990·Journal of Ethnopharmacology·M A Ajabnoor
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·U PantenC Schwanstecher
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Citations

Feb 21, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ryan BradleyLeanna J Standish
Jul 29, 2005·The American Journal of Chinese Medicine·Jing-Tian XieChun-Su Yuan
Jan 17, 2012·Nutrition Journal·Chung-Huang TsaiChing-jang Huang
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Adewale Adeneye AdejuwonEsther Oluwatoyin Agbaje
Sep 16, 2005·Journal of Ethnopharmacology·Chiu-Lan HsiehRobert Y Peng
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Cheow Peng OoiTengku-Aizan Hamid
May 20, 2018·BMC Complementary and Alternative Medicine·Gulzar Ahmad BhatBilal Ahmad Paray

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