PMID: 9159247Aug 1, 1996Paper

Application of molecular biology-based methods to the diagnosis of infectious diseases

Frontiers in Bioscience : a Journal and Virtual Library
U Reischl

Abstract

The basis for effective treatment and cure of a patient is the rapid diagnosis of the disease and its causative agent, which is founded on the analysis of the clinical symptoms coupled with laboratory tests. As we approach the 21st century, clinicians are becoming increasingly able to diagnose and treat diseases at the molecular level. The rapid development of new methods and techniques in the area of molecular biology has gained new insights into the genetic and structural features of a considerable number of human pathogens. These results obtained by intensive basic research are currently leading to improved diagnostic procedures. Basically, there are four different possibilities for laboratory diagnosis of infections: 1. direct detection of the pathogens (e.g., microscopy and/or culture), 2. detection of protein components of the pathogens with the help of specific antibodies (e.g., antigen capture ELISA) 3. IgA-, IgM- and IgG-specific detection of antibodies directed against a given pathogen and changes in their corresponding titer, and as the most sensitive method, 4. specific detection of nucleic acids (e.g., PCR) of the pathogens. Here, the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis are serving as ...Continue Reading

Citations

Oct 13, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Andrey G AzovStephen J Hamilton-Dutoit
Mar 12, 2016·International Journal of Mycobacteriology·Jenny Laura Ruiz-FuentesLucrecia Acosta
May 17, 2005·Biotechnology and Bioengineering·Gregory P StoneFrederick R Haselton
Sep 5, 2001·Clinical Genetics·N Wedemeyer, T Pötter
Jan 16, 2008·Current Opinion in Anaesthesiology·Nina C WeberBenedikt Preckel
Feb 24, 2001·Biosensors & Bioelectronics·S S IqbalJ P Chambers

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