PMID: 26797832Jan 23, 2016Paper

Application of molecular diagnostic techniques in precision medicine of personalized treatment for colorectal cancer

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Ji Fu, Guole Lin

Abstract

Precision medicine is to customize the treatment options for individual patient based on the personal genome information. Colorectal cancer (CRC) is one of the most common cancer worldwide. Molecular heterogeneity of CRC, which includes the MSI phenotype, hypermutation phenotype, and their relationship with clinical preferences, is believed to be one of the main factors responsible for the considerable variability in treatment response. The development of powerful next-generation sequencing (NGS) technologies allows us to further understand the biological behavior of colorectal cancer, and to analyze the prognosis and chemotherapeutic drug reactions by molecular diagnostic techniques, which can guide the clinical treatment. This paper will introduce the new findings in this field. Meanwhile we integrate the new progress of key pathways including EGFR, RAS, PI3K/AKT and VEGF, and the experience in selective patients through associated molecular diagnostic screening who gain better efficacy after target therapy. The technique for detecting circulating tumor DNA (ctDNA) is introduced here as well, which can identify patients with high risk for recurrence, and demonstrate the risk of chemotherapy resistance. Mechanism of tumor drug...Continue Reading

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.

Related Papers

World Journal of Gastroenterology : WJG
Tae-Min KimYeun-Jun Chung
Nihon rinsho. Japanese journal of clinical medicine
Mayuko Saito, Takayuki Yoshino
International Journal of Biological Sciences
Ada Hang-Heng Wong, Chu-Xia Deng
Salud pública de México
Alfredo Hidalgo-Miranda, Gerardo Jiménez-Sánchez
© 2022 Meta ULC. All rights reserved