Application of monodirectional Janus patch to oromucosal delivery system

Advanced Healthcare Materials
Jae Bem YouHye Sun Gwak

Abstract

Drug delivery through mucosae has received huge research attention owing to its advantageous characteristics such as accurate dose control and the avoidance of premature metabolism of vulnerable drugs by oral administration. However, body fluid in mucosae may dissolve the drug, releasing it to unwanted directions. Here, a Janus drug delivery patch with monodirectional diffusion property is devised to deliver drugs efficiently and to overcome the issue of unwanted drug release. A polyester fabric is coated with a hydrophobic polymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluorodecyl methacrylate), via initiated chemical vapor deposition. Subsequently, hydrophilicity is rendered selectively on one surface by base-catalyzed hydrolysis to obtain a Janus substrate with both hydrophobic and hydrophilic surfaces. The hydrophilic surface of the Janus substrate is further coated with resveratrol-loaded hydrogel to produce a Janus drug delivery patch. The fabricated patch efficiently blocks fluid penetration from one side to the other in mucous environment. Delivery of resveratrol through hairless mouse skin and reconstructed human mucosae using Janus patch shows higher permeation flux compared to bare control patch. The Janus ...Continue Reading

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Citations

Dec 21, 2016·Advanced Healthcare Materials·Young-Hyeon AnNathaniel S Hwang
Jul 21, 2016·Scientific Reports·Daewon KimYang-Kyu Choi
Dec 12, 2018·Advanced Materials·Lianxin ShiShutao Wang
Apr 7, 2021·Biotechnology and Bioprocess Engineering : BBE·Younghak ChoSung Gap Im

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