Application of monolithic chromatographic supports in virus research

Electrophoresis
M KrajačićI Gutierrez-Aguirre

Abstract

Key properties of monolithic chromatographic supports, make them suitable for separation and/or concentration of large biomolecules, especially virus particles and viral genomes. One by one, the studies that have been completed so far, contributed to the knowledge that monolith chromatography has hardly any limitation to be applied in virus research. Viruses of different sizes, possessing icosahedral structure and symmetrical morphology, as well as rod-shaped or filamentous viruses with helical structure, even enveloped ones, all of them could be successfully managed by means of monolith chromatography. Same is true for viral genomes, primarily when being distinct from other nucleic acid forms present in a host cell. This review is exclusively focused on viruses. It describes the application of monolith chromatography to different problematics within the virus research field. The reviewed achievements offer new possibilities and trigger new aspects in virology.

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Citations

Nov 28, 2019·Expert Opinion on Biological Therapy·Mafalda G MoleirinhoCristina Peixoto
Apr 11, 2020·Frontiers in Microbiology·Rosalind A GilbertEleanor Jameson
Jan 11, 2020·Critical Reviews in Biotechnology·Daniel LoewePeter Czermak
Sep 12, 2020·Journal of Separation Science·Fernando Henrique do NascimentoJorge Cesar Masini
Feb 13, 2021·Viruses·Christopher Perry, Andrea C M E Rayat
Mar 5, 2021·Vavilovskiĭ Zhurnal Genetiki I Selekt︠s︡ii·I D PetrovaO S Taranov
Aug 22, 2020·Journal of Chromatography. a·Patricia Pereira AguilarAlois Jungbauer
Jun 16, 2021·Journal of Separation Science·Renan VitekJorge C Masini

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