Application of MRI Radiomics-Based Machine Learning Model to Improve Contralateral BI-RADS 4 Lesion Assessment

Frontiers in Oncology
Wen HaoWeijun Peng

Abstract

This study aimed to explore the potential of magnetic resonance imaging (MRI) radiomics-based machine learning to improve assessment and diagnosis of contralateral Breast Imaging Reporting and Data System (BI-RADS) category 4 lesions in women with primary breast cancer. A total of 178 contralateral BI-RADS 4 lesions (97 malignant and 81 benign) collected from 178 breast cancer patients were involved in our retrospective dataset. T1 + C and T2 weighted images were used for radiomics analysis. These lesions were randomly assigned to the training (n = 124) dataset and an independent testing dataset (n = 54). A three-dimensional semi-automatic segmentation method was performed to segment lesions depicted on T2 and T1 + C images, 1,046 radiomic features were extracted from each segmented region, and a least absolute shrinkage and operator feature selection method reduced feature dimensionality. Three support vector machine (SVM) classifiers were trained to build classification models based on the T2, T1 + C, and fusion image features, respectively. The diagnostic performance of each model was evaluated and tested using the independent testing dataset. The area under the receiver operating characteristic curve (AUC) was used as a per...Continue Reading

References

Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·J J JobsenJ H Meerwaldt
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Meagan Elizabeth BrennanStefano Ciatto
Dec 7, 2010·The Breast Journal·Pelin Seher OztekinFahriye Karataş Oztürk
Jan 12, 2011·Breast Cancer Research and Treatment·Lidia Rosi MedeirosMaria Inês Rosa
Jun 2, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S M SchmidU Güth
May 17, 2012·Radiology·Mary C MahoneyConstance Lehman
Feb 11, 2014·Breast Cancer Research and Treatment·Daniel W VisscherLynn C Hartmann
Oct 23, 2014·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takayoshi Uematsu
Jun 24, 2015·AJR. American Journal of Roentgenology·João Ricardo Maltez de AlmeidaMário de Seixas Rocha
Oct 27, 2015·Journal of Clinical and Diagnostic Research : JCDR·Naveen PadmanabhanSelvi Radhakrishna
Jan 23, 2016·AJR. American Journal of Roentgenology·Almir G V BitencourtElvira F Marques
Jun 9, 2016·Journal of Magnetic Resonance Imaging : JMRI·Hildebrand DijkstraPaul E Sijens
Aug 8, 2017·Archives of Pathology & Laboratory Medicine·Seema B JabbarSunati Sahoo
Aug 10, 2017·AJR. American Journal of Roentgenology·Roberta M StrigelWendy B DeMartini
Sep 30, 2017·Topics in Magnetic Resonance Imaging : TMRI·Doris LeithnerKatja Pinker
Feb 6, 2018·Breast Cancer Research and Treatment·Francesca ValdoraAlberto Stefano Tagliafico
Nov 8, 2018·BioMed Research International·Paola CrivelliMaurizio Conti
May 30, 2020·Breast Cancer Research : BCR·Elizabeth J SuttonHarini Veeraraghavan

❮ Previous
Next ❯

Citations

Jul 3, 2021·Current Oncology·Filippo PesapaneEnrico Cassano
Aug 10, 2021·Frontiers in Oncology·Yu-Meng LeiChristoph F Dietrich
Aug 24, 2021·Nihon Hoshasen Gijutsu Gakkai zasshi·Koji Sakai

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
feature extraction

Software Mentioned

scikit
SimpleITK
pyradiomics
python
image
learn
matplotlib
ROCKIT
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.