Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts

Bioorganic & Medicinal Chemistry Letters
Chitalu C MusondaKelly Chibale

Abstract

The synthesis of a new class of Ugi adducts incorporating the 4-aminoquinoline moiety is described. The novel compounds are active against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum with the best compound showing an IC(50) value of 73 nM against a resistant K1 strain.

References

Aug 20, 1976·Science·W Trager, J B Jensen
Jan 7, 1972·Nature·C A HomewoodV C Baggaley
Oct 12, 2000·Angewandte Chemie·A Dömling, I Ugi
Feb 22, 2001·Antimicrobial Agents and Chemotherapy·A Singh, P J Rosenthal
Jan 30, 2002·Bioorganic & Medicinal Chemistry·Abolfasl GolisadeAndreas Link
Feb 7, 2003·Current Medicinal Chemistry·Christopher Hulme, Vijay Gore

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Citations

Mar 23, 2012·Chemical Reviews·Alexander DömlingKan Wang
Sep 24, 2013·The Journal of Organic Chemistry·Andrea F G GarganoMichael Lämmerhofer
May 16, 2006·Medicinal Research Reviews·Suryanaryana VangapanduRahul Jain
May 19, 2011·Social Neuroscience·Liane Young, James Dungan
Mar 2, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Christoph HerrmannChris Orvig
Jun 8, 2007·Emerging Infectious Diseases·Tarekegn A Abeku
Feb 11, 2020·Frontiers in Chemistry·Nashwa M SalehRana A Othman
Jun 29, 2018·Molecular Diversity·Ali Asghar MohammadiReza Ahdenov
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Odette ConcepciónClaudio A Jiménez
Feb 12, 2008·Journal of Medicinal Chemistry·Wolfgang FriebolinElisabeth Davioud-Charvet
Jun 24, 2015·ACS Combinatorial Science·Prashant B DalviChung-Ming Sun
Oct 21, 2014·Chemical Reviews·Cátia TeixeiraPaula Gomes
Nov 15, 2005·Journal of Combinatorial Chemistry·Roland E Dolle
Feb 8, 2011·European Journal of Medicinal Chemistry·S Praveen KumarRui Moreira

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Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.