Abstract
To examine the comparative effectiveness of inhaled long-acting beta-agonist (LABA), inhaled corticosteroid (ICS), and ICS/LABA combinations. We used a retrospective cohort design of patients older than 12 years with asthma diagnosis in the Clinical Practice Research Datalink to evaluate asthma-related morbidity measured by oral corticosteroid (OCS) initiation within 12 months of initiating LABAs, ICSs, or ICSs/LABAs. Asthma severity 12 months before drug initiation (use of OCSs, asthma-related hospital or emergency department visits, and number of short-acting beta-agonist prescriptions) and during follow-up (short-acting beta-agonist prescriptions and total number of asthma drug classes) was adjusted as a time-varying variable via marginal structural models. A total of 51,103 patients with asthma were followed for 12 months after receiving first prescription for study drugs from 1993 to 2010. About 92% initiated ICSs, 1% initiated LABAs, and 7% initiated ICSs/LABAs. Compared with ICSs, LABAs were associated with a 10% increased risk of asthma exacerbations requiring short courses of OCSs (hazard ratio [HR] 1.10; 95% confidence interval [CI] 1.07-1.18). ICS/LABA initiators were 62% less likely than ICS initiators (HR 0.38; 95%...Continue Reading
References
Mar 30, 1991·BMJ : British Medical Journal·H JickL E Derby
Jan 15, 1997·JAMA : the Journal of the American Medical Association·T L Petty, G G Weinmann
Feb 12, 1998·Annals of Internal Medicine·D B Rubin
Apr 22, 1999·Thorax·A HansellD Strachan
Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Aug 24, 2000·Epidemiology·M A HernánJ M Robins
Jan 23, 2002·Pharmacoepidemiology and Drug Safety·L Wood, R Coulson
Mar 22, 2002·Respiratory Medicine·P A VermeireW C Maier
May 14, 2003·Pharmacotherapy·Susan S JickHershel Jick
Aug 12, 2004·Respiratory Medicine·N S Breekveldt-PostmaR M C Herings
Feb 5, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·UNKNOWN Asia Pacific COPD Roundtable Group
Jun 5, 2008·Annals of Internal Medicine·Eric BatemanSteven Yancey
Nov 26, 2008·Pulmonary Pharmacology & Therapeutics·Gustavo J RodrigoJosé A Castro-Rodriguez
May 5, 2011·Epidemiology·David SuarezXavier Basagaña
Citations
Jun 12, 2018·Statistics in Medicine·Dirk EndersIris Pigeot
Jun 18, 2017·The European Respiratory Journal·Mohammad A Al SallakhGwyneth A Davies
Sep 17, 2019·American Journal of Respiratory and Critical Care Medicine·Eugene R BleeckerTrung N Tran
Jun 11, 2019·BMJ Open Respiratory Research·Cristina LongoTracie A Barnett