Application of natural killer T cells in antitumor immunotherapy

Critical Reviews in Immunology
Changwan Hong, Se-Ho Park

Abstract

NKT cells are a unique subset of T cells that recognize glycolipid antigens presented by CD1d molecules. NKT cells have the potential to produce key cytokines of both Th1 and Th2 T cells and are involved in the control of several types of immune response. Furthermore, NKT cells perform spontaneous tumor immunosurveillance. Upon specific activation with alpha-GalCer, NKT cells show strong antitumor immune responses through direct cytotoxicity and indirect activation of a cascade of antitumor effector cells such as natural killer (NK) cells and CD8+ cytotoxic T cells. In addition to alpha-GalCer, many other CD1d ligands, including self and bacterial glycolipids and modified synthetic glycolipid antigens, have also been discovered. Structurally different glycolipid antigens have the distinct ability to activate NKT cells. Thus, it seems that we are now close to a position in which we can control the activation status of NKT cells; this makes NKT cells an ideal target of anticancer immunotherapies. Clinical trials with soluble alpha-GalCer or alpha-GalCer-pulsed dendritic cells aimed at in vivo reconstitution and activation of human NKT cells have provided both promising and challenging results. In this review, we discuss NKT-cell-...Continue Reading

Citations

Jul 2, 2009·Environmental Health and Preventive Medicine·Shuko MurakamiTakemi Otsuki
Apr 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Alan MelcherJohn C Bell
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tonya J WebbMathias Oelke
Jun 30, 2010·International Immunopharmacology·Jason K StuartS M Mansour Haeryfar
Sep 10, 2009·Biochemical and Biophysical Research Communications·Sundo JungSe-Ho Park
Aug 9, 2015·Molecular Immunology·Wei YangJinwook Shin
Jun 12, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrick-Nikolaus NierlichThomas Wekerle
Jun 3, 2015·Glycobiology·Omid Haji-GhassemiStephen V Evans
Aug 23, 2011·Expert Review of Vaccines·Josianne Nitcheu Tefit, Vincent Serra
Nov 2, 2011·Immunology and Cell Biology·Jacqueline L HayworthS M Mansour Haeryfar
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michele W L TengMark J Smyth
Mar 12, 2011·Organic & Biomolecular Chemistry·Aline Banchet-CadedduArnaud Haudrechy
Feb 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinhong WuXiao-Ping Zhong
May 6, 2015·ACS Medicinal Chemistry Letters·Jingjing BiYuguo Du

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