Application of NMR spectroscopy to the characterization of PEG-stabilized lipid nanoparticles

Langmuir : the ACS Journal of Surfaces and Colloids
Marcos Garcia-FuentesMaria J Alonso

Abstract

The main purpose of the present work was to apply NMR techniques to characterize the nanostructural organization of a new drug nanocarrier composed of tripalmitin, lecithin, and poly(ethylene glycol) (PEG)-stearate. These nanocarriers were prepared by an emulsification-solvent evaporation technique and were characterized for their composition and nanostructural architecture. The results showed that tripalmitin, present in the core of the nanoparticles, is the main component of these systems, whereas PEG-stearate is firmly attached to the surface of the nanoparticles, forming a hydrated polymeric layer. Furthermore, the results indicate that, by selecting appropriately the composition of the lipid mixtures used for nanoparticle preparation, it was possible to modulate the PEG-coating density. This rigorous characterization by NMR provided very useful information about the architectural organization of this new colloidal drug carrier and showed the potential of modern NMR techniques for the characterization of core-coated nanostructures intended for drug delivery.

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Citations

Apr 20, 2005·Journal of Colloid and Interface Science·Marcos Garcia-FuentesDolores Torres
Jul 16, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Albert J de GraafWim E Hennink
Jan 1, 2009·Critical Reviews in Therapeutic Drug Carrier Systems·Anu PuriRobert Blumenthal
Nov 26, 2008·Nanomedicine·Maria de la FuenteMaria Jose Alonso
Jul 2, 2011·Nanomedicine·Jesse V JokerstSanjiv S Gambhir
Feb 16, 2011·Bioanalysis·Wenlei JiangLawrence X Yu
May 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Jana KucerovaZuzana Bilkova
Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jean-Michel RabanelXavier Banquy
Apr 18, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Teresa GonzaloMaria José Alonso
Sep 24, 2013·Molecular Pharmaceutics·Kevin M PustulkaChristopher W Macosko
Oct 3, 2006·Drug Development and Industrial Pharmacy·Betül Arica YeginAlf Lamprecht
Feb 13, 2016·Biomacromolecules·Emanuela Fabiola CraparoGennara Cavallaro
Sep 14, 2007·Journal of Pharmaceutical Sciences·Weiling HeZhi-Rong Zhang
May 15, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rania M Hathout, Timothy J Woodman
Apr 17, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandra StrübingKarsten Mäder
Nov 5, 2008·Journal of Biomedical Materials Research. Part a·Tania BetancourtLisa Brannon-Peppas
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Jun 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qingguo XuJustin Hanes
May 21, 2011·Journal of Colloid and Interface Science·Thomas DelmasIsabelle Texier
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May 7, 2008·Nanotechnology·A TrapaniM J Alonso
Oct 28, 2019·Drug Delivery and Translational Research·Eleni SamaridouMaria José Alonso
Feb 5, 2021·International Journal of Pharmaceutics·Aldemar Gordillo-GaleanoClaudia Elizabeth Mora-Huertas
Apr 18, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Clyde A DalyRigoberto Hernandez
Feb 21, 2021·Advanced Drug Delivery Reviews·Pyae PhyoYongchao Su
Mar 17, 2021·Biomacromolecules·Saúl A Navarro-MarchalJuan Antonio Marchal
May 1, 2021·Pharmaceutics·Supandeep Singh HallanRita Cortesi
Jul 20, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Florence FranconiPatrick Saulnier
Dec 31, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Melissa D HowardThomas D Dziubla
Jun 14, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Sjören SchweizerhofMartin Möller
Oct 26, 2007·Biomacromolecules·Julie ThevenotCatherine Ladavière

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