PMID: 16512688Mar 4, 2006Paper

Application of Number Needed to Treat (NNT) as a Measure of Treatment Effect in Respiratory Medicine

Treatments in Respiratory Medicine
Mario Cazzola

Abstract

Presentation of clinical data can have a profound effect on treatment decisions, and there is a need for measures that are objective, have clinical relevance, and are easily interpreted. Relative risk is often used to summarize treatment comparisons, but does not account for variations in baseline risk profiles and does not convey information on absolute sizes of treatment effects. Absolute risk reduction gives this information, but the data are dimensionless and abstract, and lack a direct connection with the clinical environment.The number needed to treat, or NNT, has been developed to address this issue. NNT is the reciprocal of the absolute risk reduction associated with an intervention, and may also be calculated as 100 divided by the absolute risk reduction expressed as a percentage. The result is the number of patients who would have to receive treatment for one of them to benefit or to avoid an adverse outcome over a given period of time. Since its introduction, the concept of NNT has been expanded to include number needed to harm (NNH), which illustrates adverse events or other undesirable outcomes associated with treatment, and the epidemiologic tool of number needed to screen.NNT has been used to describe treatment e...Continue Reading

References

Nov 4, 1992·JAMA : the Journal of the American Medical Association·UNKNOWN Evidence-Based Medicine Working Group
Jun 30, 1988·The New England Journal of Medicine·A LaupacisR S Roberts
Oct 21, 1995·BMJ : British Medical Journal·T FaheyT J Peters
Feb 18, 1995·BMJ : British Medical Journal·R J Cook, D L Sackett
Oct 1, 1993·Journal of General Internal Medicine·D J MalenkaJ M Ross
May 1, 1997·Annals of Internal Medicine·H J McQuay, R A Moore
Jan 10, 1998·Annals of Internal Medicine·B P Jain
Jul 31, 1998·BMJ : British Medical Journal·C M Rembold
Nov 7, 1998·BMJ : British Medical Journal·D G Altman
Jul 23, 1999·BMJ : British Medical Journal·W M Moore
Dec 14, 1999·BMJ : British Medical Journal·B G Charlton
Dec 14, 1999·BMJ : British Medical Journal·G R Thompson
Dec 3, 1999·BMJ : British Medical Journal·D G Altman, P K Andersen
Apr 17, 2001·Annals of Internal Medicine·D G AltmanUNKNOWN CONSORT GROUP (Consolidated Standards of Reporting Trials)
Feb 14, 2003·Lancet·Peter CalverleyUNKNOWN TRial of Inhaled STeroids ANd long-acting beta2 agonists study group
Feb 27, 2003·The Medical Journal of Australia·Heather Powell, Peter G Gibson
Dec 19, 2003·The European Respiratory Journal·P M CalverleyH Olsson
May 14, 2004·Evaluation & the Health Professions·Kung-Jong Lui
Aug 18, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alexandra BarrattUNKNOWN Evidence-Based Medicine Teaching Tips Working Group
May 25, 2005·Archives of Internal Medicine·Peder Andreas Halvorsen, Ivar Sønbø Kristiansen

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Citations

Apr 2, 2008·Current Allergy and Asthma Reports·David M Lang
Sep 24, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Shawn D Aaron, Dean A Fergusson
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Mario Cazzola, Nicola A Hanania
Feb 23, 2008·Gastrointestinal Endoscopy·Suzana MullerWolnei Caumo
Mar 17, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Karin BergerHelmut Ostermann
Oct 15, 2014·Pharmaceutical Statistics·Haiyuan Zhu, Xiao Wu
Oct 13, 2018·The European Respiratory Journal·Mario CazzolaMaria Gabriella Matera
Nov 27, 2015·The British Journal of Nutrition·C J BautistaE Zambrano
Sep 15, 2011·Operative Dentistry·A ReisA D Loguercio
May 1, 2021·Journal of Clinical Medicine·Luigino CalzettaAlfredo Chetta

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