PMID: 3752061Oct 1, 1986Paper

Application of odds ratio regression models for assessing familial aggregation from case-control studies

American Journal of Epidemiology
K Y LiangB H Cohen

Abstract

A regression model for estimating covariate effects on odds ratios to test for familial aggregation of common disease in first-degree relatives of cases and controls is presented and illustrated by using family data from a study of chronic obstructive pulmonary disease. These estimators are in essence an extension of the Mantel-Haenszel estimator of odds ratio but do not require the assumption of independence among relatives. A robust test statistic for possible effects of covariates such as the matching variables for cases and controls on odds ratio is also presented. In data on 156 adult first-degree relatives of 28 cases with demonstrated airway obstruction and 28 controls matched for age, sex, race, and hospital status, there appeared to be a difference in the odds ratio among families of black and white case-control pairs. However, the small sample size available prevents conclusive interpretation of this observation.

Citations

Jan 15, 1992·Statistics in Medicine·M AshbyR E Fusaro
May 6, 2003·Journal of Biopharmaceutical Statistics·Sin-Ho JungChul Ahn
Jan 5, 2020·Psychopharmacology·Merideth A AddicottJames P Selig
Mar 1, 1996·Journal of the American Statistical Association·N E Breslow
Apr 12, 2017·Childhood Obesity·Liang WangYoufa Wang
Dec 10, 1999·Journal of Periodontology·U M IrfanN F Bissada
Mar 5, 2009·The International Journal of Eating Disorders·Andréa Poyastro PinheiroCynthia M Bulik
Jan 1, 1996·Genetic Epidemiology·M E ParentA Lacroix

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