Application of optimization methodology and specimen-specific finite element models for investigating material properties of rat skull

Annals of Biomedical Engineering
Fengjiao GuanKing H Yang

Abstract

Finite element (FE) models of rat skull bone samples were developed by reconstructing the three-dimensional geometry of microCT images and voxel-based hexahedral meshes. An optimization-based material identification method was developed to obtain the most favorable material property parameters by minimizing differences in three-point bending test responses between experimental and simulation results. An anisotropic Kriging model and sequential quadratic programming, in conjunction with Latin Hypercube Sampling (LHS), are utilized to minimize the disparity between the experimental and FE model predicted force-deflection curves. A selected number of material parameters, namely Young's modulus, yield stress, tangent modulus, and failure strain, are varied iteratively using the proposed optimization scheme until the assessment index 'F', the objective function comparing simulation and experimental force-deflection curves through least squares, is minimized. Results show that through the application of this method, the optimized models' force-deflection curves are closely in accordance with the measured data. The average differences between the experimental and simulation data are around 0.378 N (which was 3.3% of the force peak val...Continue Reading

References

Oct 1, 1970·Journal of Biomechanics·J H McElhaneyN M Alem
Jan 1, 1971·Journal of Biomechanics·J L Wood
Feb 17, 1998·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·D A ReimannD P Fyhrie
Dec 4, 2003·Journal of Neurotrauma·Amit GefenSusan S Margulies
Feb 9, 2006·Acta Neurochirurgica. Supplement·A PeñaM U Schuhmann
Jun 20, 2006·Annals of Biomedical Engineering·J A W van DommelenD R Diduch
Aug 2, 2006·Computer Methods in Biomechanics and Biomedical Engineering·C KoberH-F Zeilhofer
Feb 23, 2008·Biomechanics and Modeling in Mechanobiology·A ChawlaB Karthikeyan
Jun 6, 2008·Journal of Spinal Disorders & Techniques·Yabo GuanFrank A Pintar
Oct 24, 2008·Journal of Morphology·David J DaeglingAndrew J Rapoff
Mar 5, 2010·Journal of Neurotrauma·Haojie MaoAlbert I King
Apr 8, 2010·Biomechanics and Modeling in Mechanobiology·Haojie MaoKai Yang
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cynthia M BeallYong Tang Zheng

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Citations

Dec 14, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Haojie MaoKing H Yang
Nov 30, 2012·Medical & Biological Engineering & Computing·Michael LamyRémy Willinger
Sep 4, 2012·Journal of Biomechanics·Matthew T DavisCameron Dale Bass
Jun 4, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Marco PiccininiAnselm Wiskott
Nov 22, 2016·New Directions for Student Leadership·Antron D Mahoney
Jan 23, 2021·Annals of Biomedical Engineering·Guanjun ZhangHaojie Mao

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