PMID: 16644615Apr 29, 2006Paper

Application of physiology-based pharmacokinetic and pharmacodynamic modeling to individualized target-controlled propofol infusions

Advances in Therapy
Andrea N EdgintonStefan Willmann

Abstract

This study compared the ability of the physiology-based pharmacokinetic (PBPK) model with that of compartmental models used in propofol infusion devices to predict the pharmacokinetics and pharmacodynamics of propofol in various patient groups (children, pregnant women, young men, normal weight adults, and obese adults). With a PBPK model, loss of consciousness (LOC) and recovery of consciousness (ROC) corresponded to a narrow range of brain tissue concentrations (2.2-4.0 mg/L). With the compartmental models, predicted effect concentrations were also within a narrow range at LOC, but were outside the range at ROC. In individuals of normal weight, coefficients of variation (CV) of the predicted brain or effect concentrations at LOC were in a similar range-between 18% and 32%. In obese individuals, however, interindividual CV values for brain or effect concentrations were 41% (PBPK) and 93% (compartmental). This comparison suggests the increased flexibility of PBPK models over compartmental models, the latter of which rely heavily on the patient group from which the model was derived. The incorporation of PBPK models may provide target-controlled infusions with enhanced ability to predict response in a wide variety of patients.

References

Jul 1, 1991·British Journal of Anaesthesia·B MarshG N Kenny
Nov 1, 1990·British Journal of Anaesthesia·R D JonesL J Andrew
Dec 1, 1989·British Journal of Anaesthesia·C Saint-MauriceJ L Harmey
Feb 1, 1989·Acta Anaesthesiologica Scandinavica·M ValtonenP Rosenberg
Dec 1, 1987·Anesthesia and Analgesia·E GeptsE J Douglas
Jan 1, 1995·British Journal of Anaesthesia·A A RaoofR K Verbeeck
Sep 22, 1998·Anesthesiology·T Bouillon, S L Shafer
Oct 24, 2002·British Journal of Clinical Pharmacology·Catherijne A J KnibbeMeindert Danhof
Dec 28, 2002·Anesthesiology·Gregory SlepchenkoMarc Raucoules-Aimé
Apr 17, 2003·British Journal of Anaesthesia·S E MilneS Schraag
Sep 25, 2003·British Journal of Anaesthesia·A AbsalomG N C Kenny
Apr 17, 2004·Anesthesiology·Martijn J MertensJaap Vuyk
Jul 23, 2004·Journal of Medicinal Chemistry·Stefan WillmannJennifer B Dressman
Feb 1, 2005·British Journal of Anaesthesia·M A FrölichR J Melker
Mar 19, 2005·BMC Anesthesiology·Astrid M MorinLeopold Hj Eberhart
Apr 6, 2005·Journal of Clinical Anesthesia·Andrea Casati, Marta Putzu
Jun 9, 2005·British Journal of Anaesthesia·A Absalom, G Kenny

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Citations

Aug 30, 2008·Expert Opinion on Drug Metabolism & Toxicology·Andrea N EdgintonStefan Willmann
Aug 23, 2016·The Journal of Pharmacy and Pharmacology·Manuel A BaarslagDick Tibboel
Jan 23, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Elizabeth L BrainerdJoseph J Crisco
Jun 7, 2012·Clinical Pharmacology and Therapeutics·J S BarrettB Meibohm
Oct 10, 2018·Journal of Pharmacokinetics and Pharmacodynamics·Robin MicheletAn Vermeulen

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