PMID: 20646515Jul 22, 2010Paper

Application of positron emission tomography in evaluation of Alzheimer's disease rat model

Zhonghua yi xue za zhi
Ting-ting HeJia-he Tian

Abstract

To discuss the value of 11C-PIB PET and 18F-FDG micro PET imaging in Alzheimer's disease (AD) rat model. The AD rat model was established by injection of Abeta1-40 into rat's hippocampus. Learning and memory function were estimated by the Morris water maze. Amyloid deposit and neuron loss were observed by Congo red staining and HE staining respectively. 11C-PIB PET and 18F-FDG micro PET scan were performed. Meanwhile the findings of PET imaging were compared with the results of behavior test and histology. The uptake of 18F-FDG in hippocampus of AD rat model group was lower than that of control group (P < 0.01). The Morris water maze showed that the escape latent period of rat model group was longer than that of control group (P < 0.01). Neuron loss was found in rat model brain. Thus the result of micro-PET imaging was matched with those of the Morris water maze and HE staining. 11C-PIB was specifically bound to beta-amyloid in rat model brain, the uptake of 11C-PIB in AD rat model was higher than that of control (P < 0.05). Abeta deposit was observed in Congo red staining so that the result of 11C-PIB Micro-PET imaging was matched with that of beta-amyloid deposition. 11C-PIB Micro-PET imaging shows the plaque deposition while...Continue Reading

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