PMID: 8953430Nov 1, 1996Paper

Application of radioligand receptor binding assays in the search for CNS active principles from Chinese medicinal plants

Journal of Ethnopharmacology
M ZhuJ D Phillipson

Abstract

Extracts of Schefflera bodinieri and S. delavayi (Araliaceae), Celastrus angulatus and C. orbiculatus (Celastraceae), Clerodendrum mandarinorum and C. bungei (Verbenaceae), Periploca callophylla and P. forrestii (Asclepiadaceae), Alangium platanifolium (Alangiaceae) and Uncaria rhynchophylla (Rubiaceae) were assessed for CNS activity against 18 radioligand receptor binding assays. The receptors used were alpha 1-, alpha 2- and beta-adrenoceptors, 5HT-1, 5HT-1A, 5HT-2, opiate, adenosine-1, benzodiazepine, Ca+2 channel, sulphonylureas, dopamine-1, dopamine-2, muscarinic, histamine-1, Na+/K+ ATPase, GABAA and GABAB. The results indicate that these ligand-receptor binding assays are useful for understanding the mode of action of herbal medicines and for bioassay guided fractionation of plant active ingredients.

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Citations

Jun 17, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Muthu Kumaradoss Mohan Maruga Raja, Shri Hari Mishra
Apr 15, 2014·Journal of Ethnopharmacology·Jagruti J PatelNiyati S Acharya
Jul 11, 2006·Journal of Ethnopharmacology·Ji Wook JungJong Hoon Ryu
Sep 29, 2011·Biochemical and Biophysical Research Communications·Suengmok ChoYoung-Ho Jin
Aug 9, 2011·Journal of Ethnopharmacology·Ho Joon ParkHoon Jeon
Jul 20, 1999·The Journal of Pharmacy and Pharmacology·J D Phillipson
Mar 12, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D K ArulmozhiS K Arora
Nov 3, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Richard DerbySang-Heon Lee
Sep 21, 2017·Medicines·Kenneth LundstromLong Doan Dinh

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