PMID: 6170588Jan 1, 1981Paper

Application of rat mast cell incubates as a possible short-time test for sensitizing occupational chemicals

International Archives of Occupational and Environmental Health
F DielW Oprée

Abstract

The direct action of sensitizing occupational chemicals (formaldehyde, phenol, phenylhydrazine, p-aminophenol) on rat mast cells was investigated by determination of histamine using HPLC separation and fluorimetric detection. It turned out that dispensed mast cells from immunized and non-immunized Wistar-rats are more sensitive than small-cut lung tissue slices. Passive cutaneous anaphylaxis was negative after a fortnight sensitizing experiment with the here described occupational chemicals. Short-time tests with rat mast cells reflect anaphylactoid response and are suitable for the screening of sensitizing chemicals.

References

May 1, 1978·Endocrinology·T C Theoharides, W W Douglas
Mar 1, 1979·Scandinavian Journal of Immunology·T KarlssonH Bennich
Jul 15, 1972·Biochemical Pharmacology·D Lagunoff

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Citations

Jun 17, 2015·Toxicology and Applied Pharmacology·James L WeaverKristina E Howard
Apr 11, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·N Wagner, M Podda

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.