PMID: 15344197Sep 3, 2004Paper

Application of real-time tumor-tracking and gated radiotherapy system for unresectable pancreatic cancer

Yonsei Medical Journal
Yong Chan AhnKazuo Miyasaka

Abstract

Herein is reported our experience of radiation therapy using a real-time tumor-tracking and gated radiotherapy (RTRT) system for inoperable pancreatic cancer. Three unresectable pancreatic cancer patients were treated with intraoperative electron beam radiation therapy, at the time of open biopsy, and postoperative external beam radiation therapy using an RTRT system with a 2.0 mm diameter gold ball implanted into the pancreas. The total BED'salpha/beta=10 was intended to be equivalent to that of delivering 60 Gy by 2.0 Gy/fraction, while the actual dose schedules were individualized. The movement of the pancreas was analyzed based on the 3-dimensional marker positions during the RTRT. The side effects and tumor responses were evaluated. During the RTRT course, the average movement of markers in the x (left to right), y (cranial to caudal) and z (dorsal to ventral) directions were 3.0 mm (1.7- 5.2 mm), 5.2 mm (3.5 - 6.8 mm) and 3.5 mm (2.7 - 5.1 mm), respectively. During and after the course of postoperative radiation therapy, no acute side effects of RTOG grade II or higher were detected. The objective tumor responses, as evaluated by CT scans 3 months after the treatment, were 2 partial responses and no response in one patien...Continue Reading

Citations

Oct 20, 2009·International Journal of Radiation Oncology, Biology, Physics·Seth D GoldsteinJoseph M Herman
Sep 8, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·S GwynneS Mukherjee
Oct 3, 2006·Seminars in Radiation Oncology·Steve B Jiang
May 13, 2006·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Steve B Jiang
Mar 11, 2015·Journal of Medical Imaging and Radiation Oncology·Matthew PackardAlexander Kirichenko
Feb 15, 2015·International Journal of Radiation Oncology, Biology, Physics·Florence HuguetKaryn A Goodman
Jul 10, 2012·International Journal of Radiation Oncology, Biology, Physics·Florence HuguetRoss A Abrams
Jun 20, 2008·Medical Physics·Alexei TrofimovThomas Bortfeld
Mar 24, 2007·International Journal of Clinical Oncology·Hiroki ShiratoRikiya Onimaru
Jun 22, 2019·Physics in Medicine and Biology·Jenny BertholetUwe Oelfke
Oct 11, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·J DhontJ Bertholet

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