Application of reticulated platelets to transfusion management during autologous stem cell transplantation.

OncoTargets and Therapy
Sergio Parco, Fulvia Vascotto

Abstract

The immature (or reticulated) platelet fraction (IPF) is rich in nucleic acids, especially RNA, and can be used as a predictive factor for platelet recovery in platelet immunomediated consumption or in postchemotherapy myelosuppression. Our aim was to determine if transfusions with IPF-rich solutions, during autologous peripheral blood stem cell transplantation, reduce the occurrence of bleeding and hemorrhagic complications. Transfusions were administered to 40 children, affected with hematological pathologies, who underwent autologous peripheral hematopoietic progenitor cell transplantation. There were two groups of 20 patients, one group treated with IPF-poor and the other with IPF-rich solutions. In the two groups, the conditioning regimen was the same for the same pathology (hematological pathologies: 14 acute lymphoblastic leukemia; twelve acute myelocytic leukemia; four non-Hodgkin's lymphoma; two Hodgkin's lymphoma; eight solid tumors). A new automated analyzer was used to quantify the IPF: the XE2100 (Sysmex, Kobe, Japan) blood cell counter with upgraded software. The 20 patients who received solutions with a high percentage of IPF (3%-9% of total number of infused platelets) required fewer transfusions than the 20 pat...Continue Reading

References

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Citations

Feb 14, 2015·Clinics in Laboratory Medicine·Edward C C Wong
Feb 14, 2015·Clinics in Laboratory Medicine·Sue Ellen Verbrugge, Albert Huisman
May 9, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Johannes J M L Hoffmann
Nov 26, 2020·Journal of Clinical Medicine·Noé CorpatauxWillibald Hochholzer

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Methods Mentioned

BETA
nucleic acid amplification
microenzyme-linked immunosorbent assay

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