Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology cycles (IVF, ICSI and frozen embryo transfer)

The Cochrane Database of Systematic Reviews
Baris AtaWilliam Buckett

Abstract

The female genital tract is not exposed to seminal plasma during standard assisted reproductive technology (ART) cycles. However, it is thought that the inflammatory reaction triggered by seminal plasma may be beneficial by inducing maternal tolerance to paternal antigens expressed by the products of conception, and may increase the chance of successful implantation and live birth. To assess the effectiveness and safety of application of seminal plasma to the female genital tract prior to embryo transfer in ART cycles. We searched the following databases from inception to October 2017: Cochrane Gynaecology and Fertility Group Specialised Register of Controlled Trials, Cochrane Central Register of Studies Online (CRSO), MEDLINE, Embase, CINAHL and PsycINFO. We also searched trial registers for ongoing trials, including International Clinical Trials Registry Platform (ICTRP) Search Portal and ClinicalTrials.gov. Other sources searched were; Web of Knowledge, OpenGrey, LILACS, PubMed, Google Scholar and the reference lists of relevant articles. We included randomised controlled trials (RCTs) conducted among women undergoing ART, comparing any procedure that would expose the female genital tract to seminal plasma during the period ...Continue Reading

Associated Clinical Trials

References

Oct 27, 1995·Science·A TafuriB Arnold
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·C SimónA Pellicer
Dec 1, 2000·Human Reproduction·K P TremellenC Simón
Oct 19, 2002·Journal of Reproductive Immunology·Sarah A RobertsonKelton P Tremellen
May 24, 2005·Cell and Tissue Research·Sarah A Robertson
Sep 20, 2006·Human Reproduction Update·Hanna Achache, Ariel Revel
Mar 14, 2013·American Journal of Reproductive Immunology : AJRI·Sarah A RobertsonLachlan M Moldenhauer
May 17, 2014·Journal of Assisted Reproduction and Genetics·John J Bromfield
Sep 30, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R B MayerO Shebl

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Citations

Jan 31, 2020·Physiological Reviews·John E Schjenken, Sarah A Robertson
Aug 18, 2018·The Cochrane Database of Systematic Reviews·Cindy Farquhar, Jane Marjoribanks
Nov 14, 2019·International Journal of Molecular Sciences·Carlo TicconiAsgerally Fazleabas
May 1, 2021·International Journal of Molecular Sciences·Heriberto Rodriguez-MartinezJordi Roca

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