PMID: 18200866Jan 19, 2008Paper

Application of site-specific calibration data using the CALUX by XDS bioassay for dioxin-like chemicals in soil and sediment samples

Environmental Science & Technology
Amy DindalStephen Billets

Abstract

The Chemically Activated Luciferase Gene Expression (CALUX) by Xenobiotic Detection Systems (XDS) bioassay was evaluated for the determination of the presence of dioxin and dioxin-like compounds in soil and sediment in two studies conducted under the U.S. Environmental Protection Agency's Superfund Innovative Technology Evaluation Monitoring and Measurement Technologies Program. In the first study, the results were compared with those generated by established laboratory methods (EPA Method 1613B) using high-resolution mass spectrometry (HRMS). The study results demonstrated that the technology could be used to screen for dioxin concentrations above and below threshold values (e.g., less than or greater than 1 or 50 picograms of toxicity equivalents per gram [pg TEQ/g]); however, the results were not linearly correlated to the HRMS results. A second study was initiated to evaluate performance on a site-specific basis. During the second study, the data from the XDS technology were evaluated in four ways: (1) uncalibrated to HRMS, (2) calibrated using an overall statistical model, (3) calibrated using statistical models generated on a site-specific basis, and (4) calibrated using site-specific calibration factors. The results show...Continue Reading

References

Sep 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A J MurkA Brouwer
Nov 30, 1998·Environmental Health Perspectives·M Van den BergT Zacharewski
Sep 24, 2004·Journal of Exposure Analysis and Environmental Epidemiology·Marcella WarnerPier Mario Gerthoux
Jul 11, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin Van den BergRichard E Peterson
Jul 14, 2007·Environmental Science & Technology·David J BrownGeorge C Clark

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Citations

May 9, 2014·International Journal of Environmental Research and Public Health·Ding-Yan LinTsui-Chun Tsou
Mar 20, 2009·Environmental Science and Pollution Research International·Erika AnderssonMagnus Engwall
Jul 17, 2009·Environmental Science & Technology·Masakazu KanematsuMasafumi Nakamura

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