Application of Solvent Parameters for Predicting Organogel Formation

AAPS PharmSciTech
Beibei HuSanming Li

Abstract

Solvents, accounting the majority of the organogel system, have a tremendous impact on the characteristics of gels. To date, there is a large variety of organogel systems; relatively few have been investigated in the field of structure-solvent correlation. Here, a series of solvent parameters were applied to explore the role of solvent effect on network forming and gel property, intending to build the connection between the precise solvent parameter and gel property. Among the solvent parameters, Kamlet-Taft Parameters and Hansen solubility parameters can distinguish specific types of intermolecular interactions, which could correlate solvent parameter with the gel property. From an analysis of the morphologies obtained from POM and SEM, the gelator structure has an impact on its self-assembly. For possible conformations, the gelators were investigated through XRD. The investigation of solvent-property relationship will provide a theoretical basis for controllable drug delivery implants.

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Oct 14, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Beibei HuSanming Li
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Citations

Apr 18, 2019·International Journal of Cosmetic Science·R M MartinezA R Baby

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Methods Mentioned

BETA
scanning electron microscopy
X-ray
NMR

Software Mentioned

MTA
MPA
JADE
MIA
MSA

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