Application of spectral decomposition analysis to in vivo quantification of aluminum by neutron activation analysis

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
D C ComsaS H Byun

Abstract

The toxic effects of aluminum are cumulative and result in painful forms of renal osteodystrophy, most notably adynamic bone disease and osteomalacia, but also other forms of disease. The Trace Element Group at McMaster University has developed an accelerator-based in vivo procedure for detecting aluminum body burden by neutron activation analysis (NAA). Further refining of the method was necessary for increasing its sensitivity. In this context, the present study proposes an improved algorithm for data analysis, based on spectral decomposition. A new minimum detectable limit (MDL) of (0.7+/-0.1)mg Al was reached for a local dose of (20+/-1)mSv. The study also addresses the feasibility of a new data acquisition technique, the electronic rejection of the coincident events detected by a NaI(Tl) system. It is expected that the application of this technique, together with spectral decomposition analysis, would provide an acceptable MDL for the method to be valuable in a clinical setting.

References

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May 7, 1998·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A Pejovic-MilicD R Chettle
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Sep 26, 2000·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A Pejović-MilićD R Chettle

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Citations

Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Feb 19, 2016·Journal of Alzheimer's Disease : JAD·Hedieh K Mohseni, David R Chettle
Dec 5, 2006·European Journal of Internal Medicine·Gerhard StoehrChristian Ohmann
Jul 31, 2016·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·H K MohseniW V Prestwich
Jul 27, 2005·Journal of Inorganic Biochemistry·A Pejović-MilićD R Chettle
Sep 12, 2008·Physics in Medicine and Biology· AslamF E McNeill

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