PMID: 9159249Sep 1, 1996Paper

Application of sperm antigens in immunocontraception

Frontiers in Bioscience : a Journal and Virtual Library
Rajesh K Naz

Abstract

Development of a vaccine(s) based on sperm antigens represents a promising approach for contraception. The utility of an antigen in immunocontraception is contingent upon its tissue specificity, involvement in human fertility, and immunogenicity. A number of antigens have been characterized from the sperm surface. Notable among these are LDH-C4, RSA antigens, PH-20, SP 1U, HSA-63, FA-1, FA-2 and CS-1. These antigens have been proposed as potential candidates for the development of contraceptive vaccine(s). Their current status, application, relative merits, and immunogenicity in immunocontraception are discussed in this review.

Citations

May 8, 2003·American Journal of Reproductive Immunology : AJRI·Monica N MehtaSudhir B Moodbidri
Dec 3, 1999·Immunological Reviews·R K Naz
Jul 7, 1999·Journal of Reproductive Immunology·J Frayne, L Hall

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