PMID: 9553170May 30, 1998Paper

Application of SPET using technetium-99m sestamibi in brain tumours and comparison with expression of the MDR-1 gene: is it possible to predict the response to chemotherapy in patients with gliomas by means of 99mTc-sestamibi SPET?

European Journal of Nuclear Medicine
K YokogamiS Tamura

Abstract

Technetium-99m sestamibi (MIBI) is thought to be passively taken up by metabolically active tumour cells and effluxed from them by P-glycoprotein (Pgp). This 170-kDa membrane-bound protein, encoded by the MDR-1 gene, acts as an energy-dependent efflux pump for several antineoplastic agents, resulting in multidrug resistance. For this reason, it is of interest whether the tumour's response to chemotherapy can be predicted by MIBI single-photon emission tomography (SPET). In this study, MIBI SPET was compared with thallium-201 (Tl) SPET using magnetic resonance imaging as a guide in 16 patients with untreated brain tumours [ten glioblastomas (GBs), two anaplastic astrocytomas (AAs), two low-grade gliomas (LGASs) and two metastatic brain tumours) and in four patients who had received treatment for with brain tumours (two GBs, two AAs). In addition, we investigated the expression of the MDR-1 gene and its product Pgp in the same patients, and compared the results with MIBI SPET findings. MIBI, as well as Tl, was highly accumulated and retained in the enhanced region of malignant gliomas. In addition, MIBI SPET yielded sharp and well-contrasted images, and the margin of the tumour was more clearly defined than with Tl SPET due to a ...Continue Reading

Citations

Jul 14, 2005·Progress in Neurobiology·Wolfgang Löscher, Heidrun Potschka
Aug 22, 2007·International Journal of Cancer. Journal International Du Cancer·Toshio SasajimaKazuo Mizoi
Aug 31, 2010·Nuclear Medicine Communications·Nebojsa S PetrovicVladimir B Obradovic
Dec 5, 2002·Nuclear Medicine Communications·Y YamamotoM Ohkawa
Jun 17, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·George A AlexiouAndreas D Fotopoulos
Dec 21, 2002·Clinical Nuclear Medicine·Ilknur AkErkan Vardareli
Jun 14, 2001·Nuclear Medicine Communications·Y NishiyamaM Ohkawa
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May 21, 2003·Seminars in Nuclear Medicine·François BénardRoland Hustinx
Jul 29, 2021·Clinical Nuclear Medicine·Jaber Abdulwahab AsiriFatimah Ahmed Daghas

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