Application of Spray Drying Particle Engineering to a High-Functionality/Low-Solubility Milk Thistle Extract: Powders Production and Characterization

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Francesca SansoneRita Patrizia Aquino

Abstract

Many natural compounds having antioxidant and anti-inflammatory activity are a potential target for new therapies against chronic inflammatory syndromes. The oral administration of functional herbal supplements may become a prevention strategy or therapy adjuvant for susceptible patients. A case study is our milk thistle (Silybum marianum) extract rich in silymarin complex. A water-soluble microencapsulated powder system was developed by a spray drying technique to improve the poor silymarin bioactivity after oral administration. Sodium carboxymethylcellulose (NaCMC) was employed as coating/swelling polymer matrix and sodium lauryl sulfate (SLS) as the surfactant (1:1:0.05 w/w/w). A H₂O/EtOH/acetone (50/15/35 v/v/v) solvent system was used as liquid feed. The microsystems were capable of improving the in vitro dissolution and permeation rates, suggesting an enhancement of bioactivity after oral administration. The microsystems protect the antioxidant activity of silymarin after harsh storage conditions period and do not affect the anti-inflammatory properties of the raw extract (efficient already at lower concentrations of 0.312 mg/mL) to reduce dendritic cells (DCs) inflammatory cytokine secretion after lipopolysaccharide admi...Continue Reading

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Citations

Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Di Costanzo, Ruggero Angelico
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rita P AquinoFrancesca Sansone
Apr 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tiziana EspositoTeresa Mencherini
Mar 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tiziana EspositoFrancesca Sansone

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Methods Mentioned

BETA
Light Scattering
scanning electron microscopy
differential scanning calorimetry
ELISA

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