Application of stem cells in bone repair

Skeletal Radiology
Elaine Y L WaeseWilliam L Stanford

Abstract

Bone has the ability to repair minor injuries through remodeling. However, when the host source of osteoprogenitors is compromised at the defect site, one effective treatment may be cell-based therapy, as it replenishes the area of bone loss with cells possessing osteogenic potential. This review is a concise comparison of different types of stem cells that have the potential to be used in tissue-engineered scaffolds for bone repair. The clinical use of mesenchymal stem or stromal cells isolated from the bone marrow for treating various diseases has been well documented. However, the scarcity of these cells prompts the search for alternative sources of multipotential cells such as amniotic fluid stem cells and umbilical cord perivascular cells. Embryonic stem cells are another controversial source of cells with osteogenic potential. These cells have the ability to differentiate into all cell types of the adult body. Issues such as the use of human embryos and the risk of contamination from animal-derived culture components continue to prevent the therapeutic use of ESCs. As a result, abundant research has been carried out to design defined culture conditions for culturing ESCs, and alternative strategies such as the generation ...Continue Reading

References

Nov 1, 1988·Cell and Tissue Research·C ManiatopoulosA H Melcher
Apr 1, 1993·The Journal of Bone and Joint Surgery. American Volume·F ShapiroM J Glimcher
Jun 11, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S P BruderS Kadiyala
Aug 11, 1998·The Journal of Bone and Joint Surgery. American Volume·S P BruderS Kadiyala
Nov 6, 1998·Science·J A ThomsonJ M Jones
Dec 17, 1998·Scandinavian Journal of Rheumatology·R O OreffoJ T Triffitt
Apr 2, 1999·Clinical Orthopaedics and Related Research·C R Perry
Apr 2, 1999·Science·M F PittengerD R Marshak
May 20, 1999·The Anatomical Record·K S O'Shea
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G D'IppolitoG A Howard
Nov 5, 1999·Clinical Orthopaedics and Related Research·S P Bruder, B S Fox
Feb 16, 2000·Biomaterials·J S Temenoff, A G Mikos
Jun 10, 2000·British Journal of Haematology·A EricesJ J Minguell
Feb 24, 2001·The New England Journal of Medicine·R QuartoM Marcacci
Aug 18, 2001·Arthritis and Rheumatism·C De BariF P Luyten
May 29, 2002·Gene Therapy·R J JankowskiJ Huard
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Edwin M HorwitzTed Hofmann
Feb 5, 2003·Clinical Orthopaedics and Related Research·George F MuschlerKirk Easley
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Frank C den BoerHenk J Th M Haarman
May 3, 2003·The Journal of Bone and Joint Surgery. American Volume·Jeffrey C WangJay R Lieberman
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mortaza BonyadiWilliam L Stanford
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jason L DragooProsper Benhaim
Sep 4, 2004·Stem Cells and Development·Karin GertowLars Ahrlund-Richter
Oct 20, 2004·Journal of Cellular and Molecular Medicine·D BakshR S Tuan
Feb 3, 2005·Nature Medicine·Maria J MartinAjit Varki
Feb 22, 2005·Orthopaedic Nursing·Scott D Boden
Apr 15, 2005·European Cells & Materials·S N RedmanC W Archer
Apr 30, 2005·Plastic and Reconstructive Surgery·Jason L DragooProsper Benhaim
Aug 30, 2005·Experimental Gerontology·Christine Fehrer, Günter Lepperdinger
Sep 21, 2005·Expert Reviews in Molecular Medicine·Louise A HyslopMajlinda Lako
Oct 21, 2005·Cytotherapy·E M HorwitzUNKNOWN International Society for Cellular Therapy
Jan 3, 2006·Nature Biotechnology·Tenneille E LudwigJames A Thomson
Jan 4, 2006·Biochemical and Biophysical Research Communications·Seong Eun AhnHyung Min Chung

❮ Previous
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Citations

Sep 5, 2009·Clinical and Experimental Medicine·Jean GekasOlivier François Bertrand
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kenneth M DupontRobert E Guldberg
Dec 19, 2009·Regenerative Medicine·Priya R Baraniak, Todd C McDevitt
Oct 10, 2013·Tissue Engineering. Part B, Reviews·Songsong TengMichael Jagodzinski
Dec 23, 2015·Connective Tissue Research·Kaveh Ghaleh GolabShahram Namjoy Nik
Jan 10, 2016·Journal of Bone and Mineral Metabolism·Ming-San MaGerry M Raghoebar
Jul 14, 2010·Journal of Pediatric Surgery·Justin D KleinDario O Fauza
Nov 10, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xuetao ShiDong-An Wang
Feb 1, 2015·Biological Trace Element Research·Hüseyin ApdikFikrettin Şahin
Mar 26, 2011·Orvosi hetilap·József Gábor Joó
Jul 1, 2009·Cell and Tissue Banking·Tran Cong ToaiD Michael Strong
Mar 14, 2017·Stem Cells International·Rokhsareh Rohban, Thomas Rudolf Pieber
May 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ashley B AllenRobert E Guldberg
Oct 1, 2011·International Journal of Immunopathology and Pharmacology·D VanniV Salini
Jul 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Feng-Yi CaoXian-Zheng Zhang
Jun 26, 2013·Journal of Applied Biomaterials & Functional Materials·Marta TunesiCarmen Giordano

❮ Previous
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